The Plasmodium cell-cycle: facts and questions
The Plasmodium cell-cycle: facts and questions
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DOI：
10.1080/00034989859357
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发表时间：
1998-06-01
影响因子：
--
通讯作者：
Gull, K
中科院分区：
文献类型：
--
作者：
Arnot, DE;Gull, K
疟原虫的生命周期包含几个离散的细胞周期，对其分子控制知之甚少。在恶性疟原虫生命周期的五个(或更多)DNA合成周期中，与红细胞分裂相关的五个(或更多)DNA合成周期已被最详细地研究过，因此，对于主要细胞周期事件的确切性质和时间存在争议。因此，尽管DNA合成(S期)是在裂殖子入侵后28-31h左右(着色滋养体出现后不久)开始的，但无论是流式细胞仪还是前体掺入研究都没有给出一个明确的答案，即在分裂过程中是否发生了快速和连续的G(2)期和随后的M期(有丝分裂)。这些问题和其他解释恶性疟原虫细胞周期的问题也被考虑。
The Plasmodium life-cycle contains within it several discrete cell-cycles whose molecular controls are very poorly understood. Of the five (or more) periods of DNA synthesis within the P. falciparum life-cycle, that associated with erythrocytic schizogony has been studied in the greatest detail and el en here, controversy exists as to the precise nature and timing of the major, cell-cycle events. Thus, while it is clear that DNA synthesis (S phase) starts around 28-31 h after merozoite invasion (soon after the appearance of pigmented trophozoites), neither flow-cytometric nor precursor-incorporation studies have provided a definite answer as to whether rapid and successive G(2) and then M (mitotic) phases occur during schizogony. These and other problems of interpretation of the P. falciparum cell-cycle are considered.