Endocrine complications of anorexia nervosa.
Endocrine complications of anorexia nervosa.
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DOI：
10.1186/s40337-023-00744-9
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发表时间：
2023-02-15
影响因子：
4.1
通讯作者：
Haines, Melanie S.
中科院分区：
文献类型：
--
作者：
Haines, Melanie S.
神经性厌食症（AN）治疗的一个重要组成部分是评估和管理其内分泌并发症，包括功能性低促性腺激素性性腺功能减退症和骨折风险增加。身体对慢性饥饿的适应性反应导致许多内分泌异常，其中大多数在体重恢复后是可逆的。具有治疗AN患者经验的多学科团队对于改善这种疾病患者的内分泌结局至关重要，包括对生育感兴趣的AN女性。对AN患者的男性内分泌异常以及性和性别少数的了解要少得多。在这篇文章中，我们审查的病理生理学和循证治疗的内分泌并发症的建议，在AN，以及讨论在这方面的临床研究现状。内分泌并发症在神经性厌食症中很常见。例如，妇女没有月经，男子睾丸激素水平低，甲状腺激素水平低，所有这些都被认为是适应营养不良的状态。骨密度低和骨折风险增加也是常见的并发症。在女性中，体重恢复和月经恢复是低骨密度的重要治疗方法。关于AN男性内分泌并发症的治疗知之甚少。本文就AN内分泌异常的原因及治疗作一综述。
An important component in the treatment of anorexia nervosa (AN) is the evaluation and management of its endocrine complications, including functional hypogonadotropic hypogonadism and increased fracture risk. The body’s adaptive response to chronic starvation results in many endocrine abnormalities, most of which are reversible upon weight restoration. A multidisciplinary team with experience in treating patients with AN is critical to improving endocrine outcomes in patients with this disorder, including in women with AN who are interested in fertility. Much less is understood about endocrine abnormalities in men, as well as sexual and gender minorities, with AN. In this article, we review the pathophysiology and evidence-based recommendations for the treatment of endocrine complications in AN, as well as discuss the status of clinical research in this area. Endocrine complications are common in anorexia nervosa (AN). Examples include absence of menstrual periods in women, low testosterone levels in men, and low thyroid hormone levels, all of which are considered adaptive to the state of undernutrition. Low bone density and increased risk of fractures are also common complications. In women, weight recovery and restoration of menstrual periods are important treatments for low bone density. Less is known about the treatment of endocrine complications in men with AN. In this article, we review the causes and treatment of endocrine abnormalities in AN.
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影响因子：
5.8
作者：
Fazeli, Pouneh K.;Lawson, Elizabeth A.;Klibanski, Anne
通讯作者：
Klibanski, Anne
影响因子：
6.7
作者：
Freizinger, Melissa;Franko, Debra L.;Domar, Alice D.
通讯作者：
Domar, Alice D.
影响因子：
5.8
作者：
Bhasin, Shalender;Brito, Juan P.;Yialamas, Maria A.
通讯作者：
Yialamas, Maria A.
饮食失调女性的生育治疗、双胞胎出生和意外怀孕：基于人口的出生队列的研究结果。
DOI：
10.1111/1471-0528.12503
发表时间：
2014-03
期刊：
BJOG : an international journal of obstetrics and gynaecology
影响因子：
--
作者：
Micali N;dos-Santos-Silva I;De Stavola B;Steenweg-de Graaff J;Jaddoe V;Hofman A;Verhulst FC;Steegers E;Tiemeier H
通讯作者：
Tiemeier H
DOI：
10.4088/jcp.13m08753
发表时间：
2015-01
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Eddy KT;Lawson EA;Meade C;Meenaghan E;Horton SE;Misra M;Klibanski A;Miller KK
通讯作者：
Miller KK