No effect of the Trp64Arg variant of the β3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults
No effect of the Trp64Arg variant of the β3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults
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DOI：
10.1016/j.metabol.2008.06.013
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发表时间：
2008-11-01
影响因子：
9.8
通讯作者：
Tsuji, Ichiro
中科院分区：
文献类型：
--
作者：
Kuriyama, Shinichi;Shimazu, Taichi;Tsuji, Ichiro
关于β 3肾上腺素能受体基因的色氨酸-精氨酸（Trp 64 Arg）变体的存在是否会阻碍饮食和运动干预引起的体重减轻幅度，仍存在争议。本研究的目的是比较6个月的饮食和运动干预减肥前后Trp 64 Arg变体携带者和非携带者之间的体重变化。共有37名中年日本人（12名Trp 64 Arg变异携带者和25名非携带者）参加了这项研究。基线时，两组之间的体重无显著差异。携带者和非携带者的体重均显著降低，但两组之间在这些变量的变化方面无显著差异。携带者的体重变化为-2.52 kg（95%置信区间[CI]，-3.56至-1.48），非携带者为-1.89 kg（95% CI，-2.65至-1.13），变异携带者组的变化减去变异非携带者组的变化为-0.47（95% CI，-1.97至1.02）。这些结果表明，β（3）-肾上腺素能受体基因的Trp 64 Arg变异体的存在可能不会起到主要作用，阻碍体重减轻。(C)2008年爱思唯尔公司All rights reserved.
Controversy remains as to whether the presence of the tryptophan-to-arginine (Trp64Arg) variant of the beta(3)-adrenergic receptor gene impedes the magnitude of body weight loss by diet and exercise intervention. The objectives of the present study were to compare the changes in body weight between carriers and noncarriers of the Trp64Arg variant before and after 6 months of diet and exercise interventions for weight loss. A total of 37 middle-aged Japanese individuals (12 carriers and 25 noncarriers of the Trp64Arg variant) participated in the study. There were no significant differences in body weight between the 2 groups at the baseline. There were significant reductions in body weight both in carriers and noncarriers, but no significant differences between the 2 groups with respect to changes in these variables. The weight changes were -2.52 kg (95% confidence interval [CI], -3.56 to -1.48) among carriers and -1.89 kg (95% Cl, -2.65 to -1.13) among noncarriers, and the change in the variant carrier group minUS the change in the variant noncarrier group was -0.47 (95% Cl, -1.97 to 1.02). These results suggest that the presence of the Trp64Arg variant of the beta(3)-adrenergic receptor gene may not play a major role as a hindrance to weight reduction. (C) 2008 Elsevier Inc. All rights reserved.