Population attributable fraction of Esophageal squamous cell carcinoma due to smoking and alcohol in Uganda.
Population attributable fraction of Esophageal squamous cell carcinoma due to smoking and alcohol in Uganda.
复制标题
DOI：
10.1186/s12885-016-2492-x
复制
发表时间：
2016-07-11
期刊：
影响因子：
3.8
通讯作者：
Corey KE
中科院分区：
文献类型：
--
作者：
Okello S;Churchill C;Owori R;Nasasira B;Tumuhimbise C;Abonga CL;Mutiibwa D;Christiani DC;Corey KE
尽管东非食管鳞状细胞癌（ESCC）的率很高，但在普通人群中吸烟和酒精对ESCC伯嫩的贡献尚不清楚。
我们对乌干达的Mbarara区域转诊医院进行了胃肠道内窥镜检查的患者进行了一项病例对照研究。 ESCC的风险是确定吸烟，饮酒的人口分数以及30岁或更高的成年人接受胃肠道内窥镜检查的成年人中吸烟和饮酒的组合。
我们的研究由67例和142个对照组成。 ESCC的归因分数男性的性别为55％，女性 - 49％，吸烟20％，酒精和吸烟的结合在调整性别和年龄后，由于吸烟，酒精摄入量和酒精和吸烟的组合，ESCC的人口可归因于16、10和13％。
在这一人群中，如果停止吸烟和饮酒，则避免了13％的食管鳞状细胞癌病例。
Despite the high rates and regional variation of esophageal squamous cell carcinoma (ESCC) in East Africa, the contributions of smoking and alcohol to the ESCC burden in the general population are unknown. We conducted a case-control study of patients presenting for upper gastrointestinal endoscopic examination at Mbarara Regional Referral Hospital, Uganda. Sociodemographic data including smoking and alcohol intake were collected prior to endoscopy. Cases were those with histological diagnosis of ESCC and controls were participants with normal endoscopic examination and gastritis/duodentitis or normal histology. We used odds ratios associated with ESCC risk to determine the population attributable fractions for smoking, alcohol use, and a combination of smoking and alcohol use among adults aged 30 years or greater who underwent upper gastrointestinal endoscopy. Our study consisted of 67 cases and 142 controls. Median age was 51 years (IQR 40–64); and participants were predominantly male (59 %). Dysphagia and/or odynophagia as indications for endoscopy were significantly more in cases compared to controls (72 % vs 6 %, p < 0.0001). Male gender and increasing age were statistically associated with ESCC. In the unadjusted models, the population attributable fraction of ESCC due to male gender was 55 %, female gender - 49 %, smoking 20 %, alcohol 9 % and a combination of alcohol & smoking 15 %. After adjusting for gender and age, the population attributable fraction of ESCC due to smoking, alcohol intake and a combination of alcohol & smoking were 16, 10, and 13 % respectively. In this population, 13 % of esophageal squamous cell carcinoma cases would be avoided if smoking and alcohol use were discontinued. These results suggest that other important risk factors for ESCC in southwestern Uganda remain unknown.