Contribution of metabolic syndrome components to cognition in older individuals
Contribution of metabolic syndrome components to cognition in older individuals
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DOI：
10.2337/dc06-1190
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发表时间：
2007-10-01
期刊：
影响因子：
16.2
通讯作者：
Penninx, Brenda W.
中科院分区：
文献类型：
--
作者：
Dik, Miranda G.;Jonker, Cees;Penninx, Brenda W.
目的 - 最近的证据表明，代谢综合征和炎症会影响老年认知能力下降，并且它们相互促进。然而，尚不清楚代谢综合征的各个组成部分对认知的作用是什么。 研究设计和方法 - 样本由阿姆斯特丹纵向衰老研究的 1, 183 名参与者组成，他们的年龄为 65-88 岁。对代谢综合征（美国国家胆固醇教育计划定义）及其各个组成部分以及炎症标志物 C 反应蛋白 (CRP) 和 α(1)-抗胰凝乳蛋白酶 (ACT) 进行了评估。认知评估包括一般认知（简易精神状态检查）、记忆力（语言学习测试）、流体智力（乌鸦矩阵）和信息处理速度（编码任务）。 结果 - 在样本中，36.3% 患有代谢综合征。代谢综合征与所有认知测量均显着相关（P < 0.05）。在各个组成部分中，高血糖与认知功能的相关性最强且显着（多变量调整模型；B 值表明两组之间的分数差异，范围为 - 0.38 至 -1.21）。代谢综合征与认知炎症之间存在显着的交互作用（P < 0.01-0.09）。在高炎症受试者中，代谢综合征与认知呈负相关（CRP 和 ACT 均处于最高三分位；B 值范围为 -0.86 至 - 1.94，P < 0.05），而在低炎症受试者中则不存在相关性。结论 - 患有代谢综合征的受试者比没有代谢综合征的受试者表现出较差的认知表现，尤其是那些炎症水平较高的受试者。高血糖是代谢综合征与认知相关的主要原因。
OBJECTIVE - Recent evidence suggests that the metabolic syndrome and inflammation affect cognitive decline in old age and that they reinforce each other. However, it is not known what the roles of the individual components of the metabolic syndrome on cognition are.RESEARCH DESIGN AND METHODS - The sample consisted of 1, 183 participants in the Longitudinal Aging Study Amsterdam who were aged 65-88 years. Metabolic syndrome (U.S. National Cholesterol Education Program definition) and its individual components and the inflammatory markers C-reactive protein (CRP) and alpha(1)-antichymotrypsin (ACT) were assessed. Cognitive assessments included general cognition (Mini-Mental State Examination), memory (verbal learning test), fluid intelligence (Raven's Matrices), and information processing speed (coding task).RESULTS - Of the sample, 36.3% had metabolic syndrome. Metabolic syndrome was significantly associated with all cognitive measures (P < 0.05). Of the individual components, hyperglycernia was most strongly and significantly associated with cognitive function (multivariate adjusted models; B values, indicating differences in scores between both groups, rang from - 0.38 to -1.21). There was a significant interaction between metabolic syndrome and inflammation on cognition (P < 0.01- 0.09). Metabolic syndrome was negatively associated wit cognition in subjects with high inflammation (highest tertile for both CRP and ACT; B values, ranging from -0.86 to - 1.94, P < 0.05), whereas an association was absent in subjects with low inflammation.CONCLUSIONS - Subjects with metabolic syndrome showed poorer cognitive performance than subjects without metabolic syndrome, especially those with high levels of inflammation. Hyperglycemia was the main contributor of the association of metabolic syndrome with cognition.