Aqueous Humor Levels of Cytokines in Patients with Age-Related Macular Degeneration
Aqueous Humor Levels of Cytokines in Patients with Age-Related Macular Degeneration
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DOI：
10.1159/000490153
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发表时间：
2019-01-01
期刊：
影响因子：
2.6
通讯作者：
Mizota, Atsushi
中科院分区：
文献类型：
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作者：
Mimura, Tatsuya;Funatsu, Hideharu;Mizota, Atsushi
目的：比较老年性黄斑变性（AMD）和白内障患者房水中细胞因子的水平。方法：湿性AMD组13眼，白内障组14眼。通过悬浮阵列法测定了11种因子（血管内皮生长因子受体、生长因子和炎症因子）的房水水平。结果如下：AMD组眼房水中血管内皮生长因子、可溶性血管内皮生长因子受体（sVEGFR）-1、sVEGFR-2和炎症因子（单核细胞趋化蛋白（MCP）-1、白细胞介素（IL）-6和IL-8）的水平显著高于白内障组（均p < 0.05）。相比之下，两组间房水中胎盘生长因子（PGF）、肿瘤坏死因子-a、可溶性细胞间粘附分子（sICAM）-1、IL-12（p70）和IL-13的水平无显著差异。sVEGFR-1或sVEGFR-2水平与一些炎症分子（PGF、sICAM-1、MCP-1、IL-6和IL-8）之间存在显著相关性。结论：这些结果表明，各种细胞因子/生长因子参与炎症和血管生成可能与AMD的发病机制。(C)2018 S. Karger AG，巴塞尔
Purpose: To compare aqueous humor levels of various cytokines between patients with age-related macular degeneration (AMD) and cataract patients. Methods: Thirteen eyes with wet-type AMD (AMD group) and 14 eyes with cataract (cataract group) were studied. Aqueous humor levels of 11 factors (vascular endothelial growth factor receptors, growth factors, and inflammatory factors) were measured by the suspension array method. Results: Aqueous humor levels of vascular endothelial growth factor, soluble vascular endothelial growth factor receptor (sVEGFR)-1, sVEGFR-2, and inflammatory factors (monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, and IL-8) were significantly higher in the AMD group than in the cataract group (all p < 0.05). In contrast, aqueous humor levels of placental growth factor (PGF), tumor necrosis factor-a, soluble intercellular adhesion molecule (sICAM)-1, IL-12 (p70), and IL-13 showed no significant difference between the two groups. There were significant correlations between sVEGFR-1 or sVEGFR-2 levels and some of the inflammatory molecules (PGF, sICAM-1, MCP-1, IL-6, and IL-8). Conclusions: These findings suggest that various cytokines/growth factors involved in inflammation and angiogenesis may be associated with the pathogenesis of AMD. (C) 2018 S. Karger AG, Basel