Duration of COVID-19: Data from an Italian Cohort and Potential Role for Steroids.
Duration of COVID-19: Data from an Italian Cohort and Potential Role for Steroids.
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DOI：
10.3390/microorganisms8091327
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发表时间：
2020-08-31
期刊：
影响因子：
4.5
通讯作者：
Cipollone F
中科院分区：
文献类型：
--
作者：
D'Ardes D;Pontolillo M;Esposito L;Masciarelli M;Boccatonda A;Rossi I;Bucci M;Guagnano MT;Ucciferri C;Santilli F;Di Nicola M;Falasca K;Vecchiet J;Schael T;Cipollone F
SARS-CoV-2于2019年12月从中国开始传播，导致大流行，于2020年2月到达意大利。此前在亚洲的研究表明，SARS-CoV-2病毒脱落的中位持续时间约为12-20天。我们考虑了一组从COVID-19中康复的患者，显示COVID-19症状发作和结束之间的中位病程为27.5天（四分位距（IQR）：17.0-33.2），症状发作和微生物愈合之间的中位病程（由连续两次阴性鼻咽拭子定义）为38天（IQR：31.7-50.2）。在入院时PaO 2/FiO 2比值较低（p < 0.001）、临床表现较严重（p = 0.001）和淋巴细胞计数较低（p = 0.035）的患者中，COVID-19持续时间较长，临床愈合延迟（无复发）。此外，入院时PaO 2/FiO 2比值较低和疾病越严重的患者病毒脱落时间越长（分别为p = 0.031和p = 0.032）。此外，接受皮质类固醇治疗的患者临床愈合延迟（p = 0.013）。
The diffusion of SARS-CoV-2, starting from China in December 2019, has led to a pandemic, reaching Italy in February 2020. Previous studies in Asia have shown that the median duration of SARS-CoV-2 viral shedding was approximately 12–20 days. We considered a cohort of patients recovered from COVID-19 showing that the median disease duration between onset and end of COVID-19 symptoms was 27.5 days (interquartile range (IQR): 17.0–33.2) and that the median duration between onset of symptoms and microbiological healing, defined by two consecutive negative nasopharyngeal swabs, was 38 days (IQR: 31.7–50.2). A longer duration of COVID-19 with delayed clinical healing (symptom-free) occurred in patients presenting at admission a lower PaO2/FiO2 ratio (p < 0.001), a more severe clinical presentation (p = 0.001) and a lower lymphocyte count (p = 0.035). Moreover, patients presenting at admission a lower PaO2/FiO2 ratio and more severe disease showed longer viral shedding (p = 0.031 and p = 0.032, respectively). In addition, patients treated with corticosteroids had delayed clinical healing (p = 0.013).
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