Alcohol-Endocannabinoid Interactions: Implications for Addiction-Related Behavioral Processes.
Alcohol-Endocannabinoid Interactions: Implications for Addiction-Related Behavioral Processes.
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DOI：
10.35946/arcr.v42.1.09
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发表时间：
2022
影响因子：
9.4
通讯作者：
Natividad, Luis A.
中科院分区：
文献类型：
--
作者：
Serrano, Antonia;Natividad, Luis A.
关键词：
内源性大麻素系统参与中枢神经系统的几种生理功能，包括大脑奖赏回路和情绪稳态的调节。大量证据表明，大脑内源性大麻素信号在药物诱导的奖励状态的处理，其中反复暴露困扰的活动，有助于酒精使用障碍的进展病理变化。这篇综述提供了一个叙述性总结最近的研究探索酒精暴露和内源性大麻素信号的变化，可能是酒精使用障碍的发展之间的相互作用。作者首先对综述文章进行了初步检索，以帮助识别相关文献。随后分别检索主要文献和近期研究。使用检索词“酒精/乙醇”和“内源性大麻素”，沿着涵盖强化和成瘾行为中特定目标的检索词。通过排除广泛关注精神疾病、多物质滥用、非大麻素信号脂质和其他标准的文章，进一步完善了内容。初步检索共在PubMed上获得49篇综述文章，在ScienceDirect上获得13篇，在Wiley Online上获得17篇，作者从总共16篇综述中获得信息。除了独立的搜索，这篇综述提供了来自212篇出版物的信息，包括综述和原始研究文章。该综述讨论了饮酒对大脑内源性大麻素信号传导的影响，包括内源性大麻素介导的突触传递中基于酒精的扰动，通过操纵内源性大麻素系统的信号传导元件来调节酒精相关行为，以及内源性大麻素功能失调对促进戒断诱导的焦虑样行为的影响。值得注意的是，重点放在研究探索可能的治疗相关性，在酒精使用障碍的不同阶段，支持大脑内源性大麻素的基调。
The endogenous cannabinoid system is involved in several physiological functions in the central nervous system including the modulation of brain reward circuitry and emotional homeostasis. Substantial evidence implicates brain endocannabinoid signaling in the processing of drug-induced reward states, wherein repeated exposure besets pathological changes in activity that contribute to the progression of alcohol use disorder. This review provides a narrative summary of recent studies exploring the interaction between alcohol exposure and changes in endocannabinoid signaling that may underlie the development of alcohol use disorder. The authors began with an initial search for review articles to assist in the identification of relevant literature. This was followed by separate searches for primary literature and recent studies. The search terms “alcohol/ethanol” and “endocannabinoids” were applied, along with terms that covered specific objectives in reinforcement and addiction behavior. The content was further refined by excluding articles containing a broad focus on psychiatric disorders, polysubstance abuse, non-cannabinoid signaling lipids, and other criteria. The initial search yielded a total of 49 review articles on PubMed, 13 on ScienceDirect, and 17 on Wiley Online, from which the authors garnered information from a total of 16 reviews. In addition to independent searches, this review provides information from a collection of 212 publications, including reviews and original research articles. The review discusses the effects of alcohol consumption on brain endocannabinoid signaling, including alcohol-based perturbations in endocannabinoid-mediated synaptic transmission, the modulation of alcohol-related behaviors by manipulating signaling elements of the endocannabinoid system, and the influence of dysregulated endocannabinoid function in promoting withdrawal-induced anxiety-like behavior. Notable emphasis is placed on studies exploring the possible therapeutic relevance of bolstering brain endocannabinoid tone at different stages of alcohol use disorder.
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影响因子：
3.4
作者：
Berrendero, F;Maldonado, R
通讯作者：
Maldonado, R
影响因子：
7.6
作者：
Blednov, Yuri A.;Cravatt, Benjamin F.;Harris, R. Adron
通讯作者：
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影响因子：
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作者：
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Patel S
影响因子：
4.7
作者：
Basavarajappa, Balapal S.;Yalamanchili, Ratnakumar;Hungund, Basalingappa L.
通讯作者：
Hungund, Basalingappa L.
影响因子：
--
作者：
Blankman, Jacqueline L.;Simon, Gabriel M.;Cravatt, Benjamin F.
通讯作者：
Cravatt, Benjamin F.