High performance of a unique mesoporous polystyrene-based adsorbent for blood purification.
High performance of a unique mesoporous polystyrene-based adsorbent for blood purification.
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用于血液净化的独特介孔聚苯乙烯基吸附剂的高性能
DOI：
10.1093/rb/rbw038
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发表时间：
2017-02
影响因子：
6.7
通讯作者：
Yu Y
中科院分区：
文献类型：
--
作者：
Chen J;Han W;Chen J;Zong W;Wang W;Wang Y;Cheng G;Li C;Ou L;Yu Y
采用悬浮聚合法制备了一种具有独特介孔和高表面积的多功能聚苯乙烯基吸附剂（NKU-9），用于血液净化中治疗毒素的去除。所产生的吸附剂在2至50 nm的范围内具有几乎等量的中孔分布。采用体外吸附试验，考察了不同分子量血清毒素的吸附性能，并与目前临床常用的中、美、日三种吸附剂HA-330、Cytosorb和BL-300进行了比较。结果表明，NKU-9对戊巴比妥的吸附率为81.24%，与HA-330的吸附率（81.44%）相当。后一种吸附剂目前在中国用于急性解毒治疗。达到吸附平衡，NKU-9比HA-330更快，这意味着处理时间短。对于β2-微球蛋白等中分子毒素的去除，NKU-9的选择性（98.88%）优于Cytosorb（92.80%）。此外，NKU-9显示出去除白蛋白结合的毒素（例如，对血浆中总胆红素的吸附率（80.79%）比目前临床上用于去除胆红素的阴离子交换树脂BL-300高8.4%。因此，我们的研究结果表明，新开发的吸附剂具有广泛的分布和几乎等量的介孔是一种多功能的吸附剂，可以高效地去除不同分子量的血清毒素，这可能是一个很好的血液净化吸附剂，特别是治疗疾病，传统的医疗方法是低或无效的。
A multi-functional polystyrene based adsorbent (NKU-9) with a unique mesoporous and a high surface area was prepared by suspension polymerization for removal of therapeutic toxins in blood purification. The adsorbent produced had an almost equal amount of mesopore distribution in the range from 2 to 50 nm. The adsorption of serum toxins with different molecular weights were examined by in vitro adsorption assays and compared with some clinical currently used adsorbents such as HA-330, Cytosorb and BL-300 which are produced by China, America and Japan, respectively. Test results indicated that the adsorption rate for pentobarbital by NKU-9 was 81.24% which is nearly as high as HA-330 (81.44%). The latter adsorbent is currently used for acute detoxification treatment in China. To reach adsorption equilibrium, NKU-9 was faster than HA-330, which implies short treatment time. For the removal of middle molecular toxins such as β2-microglobulin (98.88%), NKU-9 performed better adsorptive selectivity than Cytosorb (92.80%). In addition, NKU-9 showed high performance for the removal of albumin-bound toxins (e.g., bilirubin), and its adsorption rate for total bilirubin (80.79%) in plasma was 8.4% higher than that of anion exchange resin BL-300 which is currently used to eliminate bilirubin in clinic. Therefore, our results indicate that the newly developed adsorbent with a wide distribution and almost equal amount of mesopores is a multifunctional adsorbent for high efficient removal of serum toxins with different molecular weights which might be an excellent blood purification adsorbent especially to treat diseases that conventional medical methods are low or not efficient.