Identification of the neural sources of the pattern-reversal VEP
Identification of the neural sources of the pattern-reversal VEP
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DOI：
10.1016/j.neuroimage.2004.09.029
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发表时间：
2005-02-01
期刊：
影响因子：
5.7
通讯作者：
Hillyard, SA
中科院分区：
文献类型：
--
作者：
Di Russo, F;Pitzalis, S;Hillyard, SA
本研究的目的是描述视觉诱发电位（VEP）的早期成分的神经发生器的模式反转光栅。多通道头皮记录的VEP和偶极子建模技术相结合的功能性磁共振成像（fMRI）和视网膜定位映射，以估计产生的VEP组件在第一个200毫秒刺激后的皮质源的位置。偶极子的位置被播种到视觉皮层区，其中功能磁共振成像激活引起的相同的刺激。结果提供了强有力的证据表明，由模式反转刺激（N75/P85）引起的VEP的第一个主要组成部分来自初级视皮层（VI区）的表面负活动。随后的波形分量可以通过与以下皮层区域的fMRI激活非常接近的偶极子来解释：P95（MT/V5区）、P125/N135（V1区）、N150（顶横沟，TPS）、N160（腹侧枕区VP、V4 v和V4/V8）和N180（背侧枕区V3 A/V7）。这些结果提供了一个详细的时空轮廓的图案反转VEP的皮层起源，这应该提高其效用在视觉感知处理的临床和基础研究。(C)2004年爱思唯尔公司All rights reserved.
This study aimed to characterize the neural generators of the early components of the visual-evoked potential (VEP) to pattern-reversal gratings. Multichannel scalp recordings of VEPs and dipole modeling techniques were combined with functional magnetic resonance imaging (fMRI) and retinotopic mapping in order to estimate the locations of the cortical sources giving rise to VEP components in the first 200 ms poststimulus. Dipole locations were seeded to visual cortical areas in which fMRI activations were elicited by the same stimuli. The results provide strong evidence that the first major component of the VEP elicited by a pattern-reversal stimulus (N75/P85) arises from surface-negative activity in the primary visual cortex (area VI). Subsequent waveform components could be accounted for by dipoles that were in close proximity to fMRI activations in the following cortical areas: P95 (area MT/V5), P125/N135 (area V1), N150 (transverse parietal sulcus, TPS), N160 (ventral occipital areas VP, V4v, and V4/V8), and N180 (dorsal occipital areas V3A/V7). These results provide a detailed spatiotemporal profile of the cortical origins of the pattern-reversal VEP, which should enhance its utility in both clinical and basic studies of visual-perceptual processing. (C) 2004 Elsevier Inc. All rights reserved.