Intestinal Permeability of Water-Soluble Nonelectrolytes: Sugars, Amino Acids, Peptides
Intestinal Permeability of Water-Soluble Nonelectrolytes: Sugars, Amino Acids, Peptides
复制标题
水溶性非电解质的肠道渗透性：糖、氨基酸、肽
DOI：
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
G. Esposito
中科院分区：
文献类型：
--
作者：
G. Esposito
The epithelial barrier is a layer of cells separating the lumen (the external environment) from the internal milieu of the organism. Most of these cells are columnar absorbing cells, also named enterocytes. Their main function is to absorb and/or secrete solutes and water selectively. Many of these solutes are water-soluble nonelectrolyte molecules such as nutrients, e.g., sugars and amino acids. In order to be transported from the lumen to the subepithelial spaces and then to the bloodstream or the lymph, these molecules must cross two in-series plasma membranes: the brush border and the basolateral membrane. However, these substances have dimensions that hinder their movement through water pores of plasma membranes or even through junctional complexes between cells; therefore, specific transport mechanisms have developed to allow the transepithelial movement of these solutes. In order to achieve a net transport, these mechanisms must be asymmetrically distributed in the two opposite plasma membranes: the luminal and the contraluminal (Fig. 1).
酚酞和骆驼蓬碱引起大鼠空肠和肾皮质分离刷状缘和基底外侧膜囊泡运输功能的紊乱。
影响因子：
5.8
作者：
Im,WB;Misch,DW;Powell,DW;Faust,RG
通讯作者：
Faust,RG