Measuring the thickness of the human cerebral cortex from magnetic resonance images
Measuring the thickness of the human cerebral cortex from magnetic resonance images
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DOI：
10.1073/pnas.200033797
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发表时间：
2000-09-26
影响因子：
11.1
通讯作者：
Dale, AM
中科院分区：
文献类型：
--
作者：
Fischl, B;Dale, AM
精确和自动化的测量人类大脑皮层厚度的方法可以为诊断和研究各种神经退行性疾病和精神疾病提供强大的工具。从神经影像学数据估计皮质厚度的手动方法是劳动密集型的，需要训练有素的解剖学家几天的努力。此外，皮质的高度折叠性质对于手动技术是有问题的，经常导致皮质表面不垂直于任何主轴的区域中的测量误差。因此，获得个体受试者整个皮质的准确厚度估计值或患者或对照人群的组统计数据是不切实际的。这里.我们提出了一种自动化方法，用于精确地测量整个大脑的大脑皮层的厚度，并用于在基于皮层解剖学的坐标系中生成跨对象统计。显示厚度测量的受试者间标准差小于0.5 mm，这意味着能够在小群体甚至个体受试者中检测局灶性萎缩。这种新方法的可靠性和准确性进行了评估，在主题内的重测研究，以及通过比较跨学科的区域厚度测量与公布的值。
Accurate and automated methods for measuring the thickness of human cerebral cortex could provide powerful tools for diagnosing and studying a variety of neurodegenerative and psychiatric disorders. Manual methods for estimating cortical thickness from neuroimaging data are labor intensive, requiring several days of effort by a trained anatomist. Furthermore, the highly folded nature of the cortex is problematic for manual techniques, frequently resulting in measurement errors in regions in which the cortical surface is not perpendicular to any of the cardinal axes. As a consequence, it has been impractical to obtain accurate thickness estimates for the entire cortex in individual subjects, or group statistics for patient or control populations. Here. we present an automated method for accurately measuring the thickness of the cerebral cortex across the entire brain and for generating cross-subject statistics in a coordinate system based on cortical anatomy. The intersubject standard deviation of the thickness measures is shown to be less than 0.5 mm, implying the ability to detect focal atrophy in small populations or even individual subjects. The reliability and accuracy of this new method are assessed by within-subject test-retest studies, as well as by comparison of cross-subject regional thickness measures with published values.