50 years of spermatogenesis: Sertoli cells and their interactions with germ cells.
50 years of spermatogenesis: Sertoli cells and their interactions with germ cells.
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DOI：
10.1093/biolre/ioy027
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发表时间：
2018-07-01
影响因子：
3.6
通讯作者：
Griswold MD
中科院分区：
文献类型：
--
作者：
Griswold MD
Sertoli细胞的复杂形态及其与生殖细胞的相互作用自Enrico Sertoli首次描述以来一直是研究者关注的焦点。在过去的50年里，支持细胞的信息已经超越了形态学本身，越来越多地关注分子问题。研究人员的目标是了解支持细胞在精子发生中的作用，并将这些信息应用于与男性生育力有关的问题。支持细胞的独特之处在于，它们是一种非分裂细胞群，在动物的生殖寿命中活跃，并周期性地改变形态和基因表达。由支持细胞产生的众多独特的连接复合物和膜特化为生殖细胞发育提供了支架和环境。研究人员越来越关注睾丸细胞的分子组成和推定功能，主要是由于从睾丸环境中分离特定细胞类型的程序。支持细胞的产物影响生殖细胞的发育，反之亦然，其特征来自培养的细胞和转基因技术的应用。生殖细胞移植已经表明，支持细胞对生殖细胞的发育时机的提示作出反应，并进一步关注生精干细胞和干细胞生态位。生精过程中非常基本和普遍的特征，如生精上皮细胞周期和生精波，都是由支持细胞启动，并由支持细胞-生殖细胞协同维持。
The complex morphology of the Sertoli cells and their interactions with germ cells has been a focus of investigators since they were first described by Enrico Sertoli. In the past 50 years, information on Sertoli cells has transcended morphology alone to become increasingly more focused on molecular questions. The goal of investigators has been to understand the role of the Sertoli cells in spermatogenesis and to apply that information to problems relating to male fertility. Sertoli cells are unique in that they are a nondividing cell population that is active for the reproductive lifetime of the animal and cyclically change morphology and gene expression. The numerous and distinctive junctional complexes and membrane specializations made by Sertoli cells provide a scaffold and environment for germ cell development. The increased focus of investigators on the molecular components and putative functions of testicular cells has resulted primarily from procedures that isolate specific cell types from the testicular milieu. Products of Sertoli cells that influence germ cell development and vice versa have been characterized from cultured cells and from the application of transgenic technologies. Germ cell transplantation has shown that the Sertoli cells respond to cues from germ cells with regard to developmental timing and has furthered a focus on spermatogenic stem cells and the stem cell niche. Very basic and universal features of spermatogenesis such as the cycle of the seminiferous epithelium and the spermatogenic wave are initiated by Sertoli cells and maintained by Sertoli-germ cell cooperation.
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影响因子：
3.6
作者：
BORLAND, K;MUFFLY, KE;HALL, PF
通讯作者：
HALL, PF
影响因子：
3.6
作者：
De Gendt, Karel;McKinnell, Chris;Verhoeven, Guido
通讯作者：
Verhoeven, Guido
影响因子：
3.6
作者：
Evans, Elizabeth;Hogarth, Cathryn;Griswold, Michael
通讯作者：
Griswold, Michael
DOI：
10.1073/pnas.0807297105
发表时间：
2008-09-30
影响因子：
11.1
作者：
Anderson, Ericka L.;Baltus, Andrew E.;Page, David C.
通讯作者：
Page, David C.
影响因子：
--
作者：
ERICKSONLAWRENCE, M;ZABLUDOFF, SD;WRIGHT, WW
通讯作者：
WRIGHT, WW