Involvement of FcRγ in signal transduction of osteoclast-associated receptor (OSCAR)
Involvement of FcRγ in signal transduction of osteoclast-associated receptor (OSCAR)
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DOI：
10.1093/intimm/dxh103
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发表时间：
2004-07-01
影响因子：
4.4
通讯作者：
Saito, T
中科院分区：
文献类型：
--
作者：
Ishikawa, S;Arase, N;Saito, T
破骨细胞调节骨发育的稳态。破骨细胞发育缺陷导致石骨症。破骨细胞相关受体（OSCAR）是破骨细胞分化的关键分子之一。然而，OSCAR如何转导破骨细胞分化的信号仍不清楚。在这里，我们发现Fc受体的信号转导衔接分子FcR γ链与OSCAR相关，并参与OSCAR的细胞表面表达。此外，FcR γ是OSCAR信号转导所必需的。这些结果表明，FcR γ介导的信号转导OSCAR参与破骨细胞分化。
Osteoclasts regulate homeostasis of bone development. A defect in osteoclast development results in osteopetrosis. Recently, the involvement of several molecules in osteoclast development has been found. Osteoclast-associated receptor (OSCAR) is one of such molecules critical for osteoclast differentiation. However, it remains unclear how OSCAR transduces signals for osteoclast differentiation. Here, we found that the FcRgamma chain, a signal transducing adaptor molecule for Fc receptors, is associated with OSCAR and is involved in the cell surface expression of OSCAR. Furthermore, FcRgamma is required for signal transduction by OSCAR. These findings suggest that the FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation.