Skin sympathetic function in complex regional pain syndrome type 1
Skin sympathetic function in complex regional pain syndrome type 1
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1 型复杂区域疼痛综合征的皮肤交感功能
DOI：
10.1007/s10286-015-0314-x
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Kuwabara S
中科院分区：
文献类型：
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作者：
Poudel A;Asahina M;Fujinuma Y;Yamanaka Y;Katagiri A;Araki N;Hirano S;Kuwabara S
目的复杂区域疼痛综合征1型（CRPS-1）的皮肤交感神经病理生理机制尚未完全清楚。为了评估CRPS-1的皮肤交感神经功能障碍，我们评估了CRPS-1 patients.MethodsWe研究了10名CRPS-1患者（年龄41 ± 13岁; 5名女性和5名男性;病程20 ± 22个月）和10名健康受试者（年龄44 ± 13岁; 3名女性和7名男性）的交感神经汗液反应（SSwR）和皮肤血管反射（SkVR）。几个交感神经激活程序的SkVR和SSwRs记录在手掌的CRPS-1患者（患侧）和对照组（右侧）。ResultsThere是没有显着差异的基线之间的CRPS-1和对照组的汗液输出量和皮肤血流量。CRPS-1组的SSwR和SkVR振幅显著低于对照组。疾病持续时间和SSwR或SkVR振幅之间没有显着的相关性patients.ConclusionsThe减少SSwR和SkVR在我们的CRPS-1患者的患肢可能反映潜在的损害交感神经节后纤维。
PurposeCutaneous sympathetic pathophysiology in complex regional pain syndrome type 1 (CRPS-1) is not yet completely understood. To evaluate cutaneous sympathetic dysfunction in CRPS-1, we evaluated sympathetic sweat response (SSwR) and skin vasomotor reflex (SkVR) in CRPS-1 patients.MethodsWe studied 10 CRPS-1 patients (age 41 ± 13 years; 5 females and 5 males; disease duration 20 ± 22 months) and 10 healthy subjects (age 44 ± 13 years; 3 females and 7 males). SkVRs and SSwRs to several sympathetic activating procedures were recorded on the palms of the CRPS-1 patients (affected side) and controls (right side).ResultsThere were no significant differences in the baselines of sweat output and skin blood flow between the CRPS-1 and control groups. SSwR and SkVR amplitudes were significantly lower in the CRPS-1 group than in the control group. There was no significant correlation between disease duration and SSwR or SkVR amplitudes among the patients.ConclusionsThe reduced SSwRs and SkVRs in the affected limb of our CRPS-1 patients may reflect underlying damage to the sympathetic postganglionic fibres.