FDG-PET and CSF phospho-tau for prediction of cognitive decline in mild cognitive impairment
FDG-PET and CSF phospho-tau for prediction of cognitive decline in mild cognitive impairment
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DOI：
10.1016/j.pscychresns.2006.12.002
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发表时间：
2007-07-15
影响因子：
2.3
通讯作者：
Mueller, Matthias J.
中科院分区：
文献类型：
--
作者：
Fellgiebel, Andreas;Scheurich, Armin;Mueller, Matthias J.
皮质葡萄糖代谢紊乱和CSF磷酸化tau（p-tau（181））浓度升高的特定模式可预测遗忘型轻度认知障碍（MCI）的认知下降和向痴呆的转变。但迄今为止，还没有对这两种诊断工具进行比较。本研究的目的是比较F-18-氟-2-脱氧-D-葡萄糖正电子发射断层扫描（FDG-PET）结果和CSF磷酸化tau（p-tau（181））测量在预测MCI患者认知恶化和转化为痴呆方面的作用。在随访期间（平均19个月），16名患者中有8名（50%）表现出进行性认知功能下降，4名患者转变为痴呆。病理性FDG-PET和p-tau（181）水平升高均预测恶化。虽然p-tau（181）对认知功能下降高度敏感，但FDG-PET在预测MCI患者转化为临床痴呆方面具有上级优势。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Specific patterns of cortical glucose metabolism disturbances and increased CSF phospho-tau (p-tau(181)) concentrations could be demonstrated to predict cognitive decline and shift to dementia in amnestic mild cognitive impairment (MCI). But comparisons of both diagnostic tools have not been undertaken so far. The aim of the study was to compare F-18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) findings and CSF phospho-tau (p-tau(181)) measurements in the prediction of cognitive deterioration and conversion to dementia in MCI. During follow-up (mean 19 months) eight of 16 patients (50%) showed progressive cognitive decline, and four patients shifted to dementia. Pathological FDG-PET and elevated p-tau(181) levels both predicted deterioration. While p-tau(181) was highly sensitive for cognitive decline, FDG-PET was superior in predicting conversion to clinical dementia in MCI patients. (c) 2007 Elsevier Ireland Ltd. All rights reserved.