Persistence of Helicobacter pylori in conventionalized piglets.
Persistence of Helicobacter pylori in conventionalized piglets.
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幽门螺杆菌在常规仔猪中的持续存在。
DOI：
10.1093/infdis/161.6.1299
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Krakowka,S
中科院分区：
文献类型：
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作者：
Eaton,KA;Morgan,DR;Krakowka,S
在3日龄时用幽门螺杆菌（弯曲杆菌）攻击无菌仔猪，然后在24日龄时转移到常规圈养中。攻毒后43-45、57-60和87-90天处死仔猪。除攻毒后45天处死的2头仔猪外，所有攻毒仔猪的胃中均回收到幽门螺杆菌。未感染的对照仔猪中未回收到幽门螺杆菌。除了H。pylori、乳酸杆菌和芽孢杆菌。感染仔猪血清中含有H.幽门特异性IgG、IgM和伊加。IgM滴度在攻毒后14天达到峰值，然后下降。IgG和伊加滴度在实验过程中持续上升。未感染对照组和攻击组的仔猪均表现出淋巴滤泡性胃炎，但攻击组仔猪的胃炎更严重。
Gnotobiotic piglets were challenged at 3 days of age withHelicobacter (Campylobacter) pyloriand then transferred to conventional housing at 24 days of age. Piglets were sacrificed 43-45, 57-60, and 87-90 days after challenge.H. pyloriwas recovered from the stomachs of all piglets challenged except for two piglets sacrificed 45 days after challenge.H. pyloriwas not recovered from uninfected control piglets. In addition toH. pylori,LactobacillusandBacillusspecies were recovered from conventionalized piglets. Serum from infected piglets containedH. pylori-specific IgG, IgM, and IgA. IgM titers peaked at 14 days after challenge and then declined. IgG and IgA titers continued to rise over the course of the experiment. Piglets in both uninfected control and challenged groups demonstrated lymphofollicular gastritis, but the gastritis was more severe in challenged piglets.