Application of bone marrow mesenchymal stem cells to the treatment of osteonecrosis of the femoral head.
Application of bone marrow mesenchymal stem cells to the treatment of osteonecrosis of the femoral head.
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发表时间：
2015-03
影响因子：
0.1
通讯作者：
Cheng Wang;Yu Wang;H. Meng;Xue-ling Yuan;Xiao-long Xu;Ai-yuan Wang;Q. Guo;Jiang Peng;Shibi Lu
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作者：
Cheng Wang;Yu Wang;H. Meng;Xue-ling Yuan;Xiao-long Xu;Ai-yuan Wang;Q. Guo;Jiang Peng;Shibi Lu
股骨头坏死（Osteonecrosis of the femoral head，ONFH）是骨科临床常见的难治性疾病，主要是由于股骨头供血部分受阻而引起的一系列病理过程。间充质干细胞（Mesenchymal stem cells，MSCs）是骨髓组织中具有多向分化潜能的多种干细胞的混合体。它们在特定条件下可分化为骨细胞，并可通过细胞移植用于治疗ONFH。本文综述了近年来骨髓间充质干细胞在股骨头坏死领域的研究进展，揭示了骨髓间充质干细胞的内在特性，描述了骨髓间充质干细胞治疗股骨头坏死的潜力，并分析了骨髓间充质干细胞在临床应用中存在的挑战。
Osteonecrosis of the femoral head (ONFH) is a type of common and refractory disease in the orthopedic clinic that is primarily caused by a partial obstruction of the blood supply to the femoral head, resulting in a series of pathological processes. Mesenchymal stem cells (MSCs) comprise a mixture of various stem cells in myeloid tissue with multipotential differentiation capacity. They can differentiate into bone cells under specific conditions and can be used to treat ONFH through cell transplantation. This review summarizes research on MSCs in the field of ONFH in recent years, reveals the inner characteristics of MSCs, describes their potential to treat osteonecrosis disease, and analyzes the existing challenges of using MSCs in clinical applications.