S144 Quality Of Life In Idiopathic Pulmonary Arterial Hypertension Is Associated With Quadriceps Function And Size
S144 Quality Of Life In Idiopathic Pulmonary Arterial Hypertension Is Associated With Quadriceps Function And Size
复制标题
S144 特发性肺动脉高压的生活质量与股四头肌功能和大小相关
DOI：
10.1136/thoraxjnl-2014-206260.150
复制
发表时间：
2014
期刊：
影响因子：
10
通讯作者：
Garfield B
中科院分区：
文献类型：
--
作者：
Garfield B
特发性肺动脉高压（IPAH）患者的生活质量（QOL）仍显着下降，尽管近年来治疗方法有所改进。肌肉功能障碍和低体力活动正在成为该疾病的重要并发症。单独的康复计划已被证明会导致生活质量和肌肉力量的改善，但这些因素之间的直接关系尚未被记录在this condition.AimsWe旨在定义IPAH患者的生活质量和肌肉功能，大小和体力活动之间的关系。股直肌的超声横截面积（USRFCSA）、通过生物电阻抗（FFMI）的无脂肪质量指数、使用Sensewear臂带的身体活动（每天步数、总能量消耗（TEE）和主动能量消耗（AEE））。他们还被要求完成圣乔治呼吸问卷（SGRQ）。Pearson或斯皮尔曼的test.ResultsIn 12例患者的数据，到目前为止，在这项研究中的总SGRQ评分测量QOL与QMVC/BMI（r =-0. 75，p = 0. 005），FFMI（r =-0. 71，p = 0. 009）和USRFCSA（r =-0. 88，p = 0. 0002）显着相关（图1A）。在9名有数据可用的患者中，SGRQ总分与Sensewear测量的每日步数（r =-0.62，p = 0.08）（图1B）、TEE（r =-0.62，p = 0.08）或AEE（rho =-0.41，p > 0.05）之间无显著相关性。此外，BNP或静息超声心动图参数与总SGRQ QOL之间无显著相关性。讨论我们已经表明，肌肉大小和功能与IPAH患者的QOL直接相关。这项工作表明，肌肉功能可能是这些患者生活质量的重要决定因素，使其成为治疗干预的潜在目标。需要进一步的数据来确定IPAH患者的体力活动和QOL之间的关系。
IntroductionDespite recent improvements in therapy patients with idiopathic pulmonary arterial hypertension (IPAH) still suffer with significantly reduced quality of life (QOL). Muscle dysfunction and low physical activity are emerging as important complications of the disease. Separately rehabilitation programs have been shown to cause an improvement in both QOL and muscle strength but the direct relationship between these factors has not as yet been documented in this condition.AimsWe aimed to define the relationship between QOL and muscle function, size and physical activity in patients with IPAH.MethodsIn 12 patients with IPAH we measured quadriceps maximal volitional capacity (QMVC), ultrasound cross sectional area of the rectus femoris (USRFCSA), fat free mass index by bioelectrical impedance (FFMI), physical activity using the Sensewear armband (steps per day, total energy expenditure (TEE), and active energy expenditure (AEE)). They were also asked to complete the St. George’s respiratory questionnaire (SGRQ). Correlations were performed with Pearson’s or Spearman’s test.ResultsIn the 12 patients with data so far available in this study QOL measured by the total SGRQ score correlated significantly with QMVC/BMI (r = -0.75, p = 0.005), FFMI (r = -0.71, p = 0.009) and USRFCSA(r = -0.88, p = 0.0002) (Figure 1A). There was no significant correlation between total SGRQ score and Sensewear measured steps per day (r = -0.62, p = 0.08) (Figure 1B) TEE (r = -0.62, p = 0.08) or AEE (rho = -0.41, p > 0.05) in the 9 patients with data available. Furthermore there was no significant correlation between BNP or resting echocardiographic parameters and total SGRQ QOLDiscussionWe have shown that muscle size and function are directly related to QOL in patients with IPAH. This work suggests that muscle function may be an important determinant of QOL in these patients, making it a potential target for therapeutic intervention. Further data is needed to define the association between physical activity and QOL in patients with IPAH.