A Randomized Controlled Trial to Increase Navy Bean or Rice Bran Consumption in Colorectal Cancer Survivors
A Randomized Controlled Trial to Increase Navy Bean or Rice Bran Consumption in Colorectal Cancer Survivors
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DOI：
10.1080/01635581.2016.1224370
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发表时间：
2016-01-01
影响因子：
2.9
通讯作者：
Ryan, Elizabeth P.
中科院分区：
文献类型：
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作者：
Borresen, Erica C.;Brown, Dustin G.;Ryan, Elizabeth P.
食用海军豆（NB）和米糠（RB）已被证明可以抑制结肠癌的发生。鉴于结直肠癌（CRC）幸存者的整体饮食质量较差，并且据报道全谷物和豆类摄入量较低，增加消费的实用策略值得关注。这项研究确定了在 CRC 幸存者中增加 NB 或 RB 摄入量以增加膳食纤维的可行性，并检查了血清炎症生物标志物和端粒长度。 29 名受试者完成了一项随机对照试验，所用食物包括煮熟的 NB 粉末（35 克/天）、热稳定 RB（30 克/天）或不含其他成分。收集空腹血液、食物记录和胃肠道健康调查问卷。 NB 或 RB 的消耗量相当于受试者每日热量摄入的 4-9%，并且没有报告随着消耗量的增加而出现严重的胃肠道问题。与基线和对照组相比，第 2 周和第 4 周，NB 组和 RB 组的膳食纤维含量有所增加 (P0.01)。端粒长度与基线时的年龄和 HDL 胆固醇相关，并与第 4 周时血清淀粉样蛋白 A (SAA) 水平的改善相关 (P0.05)。这项研究得出的结论是，将饮食中 NB 和 RB 的摄入量增加到与 CRC 化学预防相关的水平是可行的，并需要对高危人群中的这两种食物进行长期研究，包括癌症预防和控制结果。
Consumption of navy beans (NB) and rice bran (RB) have been shown to inhibit colon carcinogenesis. Given the overall poor diet quality in colorectal cancer (CRC) survivors and low reported intake of whole grains and legumes, practical strategies to increase consumption merit attention. This study determined feasibility of increasing NB or RB intake in CRC survivors to increase dietary fiber and examined serum inflammatory biomarkers and telomere lengths. Twenty-nine subjects completed a randomized controlled trial with foods that included cooked NB powder (35g/day), heat-stabilized RB (30g/day), or no additional ingredient. Fasting blood, food logs, and gastrointestinal health questionnaires were collected. The amount of NB or RB consumed equated to 4-9% of subjects' daily caloric intake and no major gastrointestinal issues were reported with increased consumption. Dietary fiber amounts increased in NB and RB groups at Weeks 2 and 4 compared to baseline and to control (P0.01). Telomere length correlated with age and HDL cholesterol at baseline, and with improved serum amyloid A (SAA) levels at Week 4 (P0.05). This study concludes feasibility of increased dietary NB and RB consumption to levels associated with CRC chemoprevention and warrants longer-term investigations with both foods in high-risk populations that include cancer prevention and control outcomes.