Correlation between transcription factor Snail1 expression and prognosis in adenoid cystic carcinoma of salivary gland
Correlation between transcription factor Snail1 expression and prognosis in adenoid cystic carcinoma of salivary gland
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唾液腺腺样囊性癌转录因子Snail1表达与预后的相关性
DOI：
10.1016/j.tripleo.2010.06.015
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发表时间：
2010-12-01
期刊：
影响因子：
--
通讯作者：
Liang, Xinhua
中科院分区：
文献类型：
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作者：
Jiang, Jian;Tang, Yaling;Liang, Xinhua
目标。转录因子Snail1在上皮-间充质转化(EMT)的诱导中起核心作用。本研究旨在探讨涎腺腺样囊性癌(ACC)中Snail1的表达与临床病理因素及预后的关系。检索121例涎腺ACC的人口学变量、原发肿瘤部位、诊断日期、神经侵袭、局部区域复发和远处转移。用免疫组织化学方法检测所有病例的Snail1表达。采用卡方检验分析Snail1表达与临床病理变量的关系，单因素和多因素分析影响预后的因素。结果显示，58.68%(71/121)的病例Snail1表达阳性。Snail1的表达与ACC患者的组织学类型、神经侵袭、局部复发和远处转移显著相关(P<；0.05)。Snail1的表达、局部区域复发和远处转移是所有患者独立且有意义的预后因素。Snail1可能在ACC的侵袭和转移中起重要作用，Snail1有可能成为ACC患者的一个强有力的预后指标。《口腔外科》《口腔医学》《口腔病理学》，《口腔放射科》2010；110：764-769)
Objective. Transcription factor Snail1 has a central role in induction of epithelial-mesenchymal transition (EMT). The aim of the present study was to study the association of Snail1 expression with clinicopathologic factors and prognosis in adenoid cystic carcinoma (ACC) of salivary gland.Study design. Demographic variables and primary tumor site, dates of diagnoses, perineural invasion, local regional recurrence, and distant metastasis of 121 cases of salivary ACC were retrieved. The Snail1 expression of all these cases was examined by immunohistochemical methods. The association between Snail1 expression and clinicopathologic variables was analyzed using chi-square test, and the prognostic factors were examined by univariate and multivariate analyses.Results. Our data demonstrated that the positive expression of Snail1 was observed in 58.68% (71/121) of cases. Snail1 expression was significantly associated with histologic pattern, perineural invasion, local regional recurrence, and distant metastasis of patients with ACC (P < .05). And Snail1 expression, local regional recurrence, and distant metastasis were independent and significant prognostic factors in all patients.Conclusion. Snail1 may play an important role in the invasion and metastasis of ACC, and Snail1 has the potential for being a strong prognosis indicator at presentation of ACC patients. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:764-769)