Nectins and nectin-like molecules: Roles in cell adhesion, polarization, movement, and proliferation
Nectins and nectin-like molecules: Roles in cell adhesion, polarization, movement, and proliferation
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DOI：
10.1080/15216540600719622
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发表时间：
2006-05-01
期刊：
影响因子：
4.6
通讯作者：
Takai, Yoshimi
中科院分区：
文献类型：
--
作者：
Ogita, Hisakazu;Takai, Yoshimi
果胶和果胶样分子(Necl)是免疫球蛋白样细胞黏附分子，分别由四个和五个成员组成的家族。除Necl-5外，所有成员都以同源的方式反式相互作用。此外，包括NECL-5在内的所有成员都与成员中各自的特定伙伴异亲性地相互作用。Necl-5与整合素α(V)、β(3)和生长因子受体协同调节细胞的运动和增殖。Nectins作为细胞间的黏附分子，作用于多种细胞间连接，包括黏附连接，并调节细胞间连接形成的初始步骤。Nectins和整合素α(V)β(3)进一步参与细胞-基质和细胞-细胞连接之间的串扰。因此，Nextin和Necl家族成员都在细胞的基本功能中发挥着重要作用，包括细胞黏附、极化、运动和增殖。
Nectins and nectin-like molecules (Necls) are immunoglobulin-like cell adhesion molecules that constitute families containing four and five members, respectively. All members, except for Necl-5, trans -interact homophilically. Furthermore, all members, including Necl-5, trans -interact heterophilically with their respective specific partners among the members. Necl-5 regulates cell movement and proliferation cooperatively with integrin alpha(v)beta(3) and growth factor receptors. Nectins function as cell-cell adhesion molecules at a variety of cell-cell junctions, including adherens junctions, and regulate the initial step of cell-cell junction formation. Nectins and integrin alpha(v)beta(3) are further involved in the cross-talk between cell-matrix and cell-cell junctions. Thus, both nectin and Necl family members play important roles in fundamental cellular functions, including cell adhesion, polarization, movement, and proliferation.