An ESIPT based fluorescence probe for ratiometric monitoring of nitric oxide
An ESIPT based fluorescence probe for ratiometric monitoring of nitric oxide
复制标题
DOI：
10.1016/j.snb.2017.12.073
复制
发表时间：
2018-04-15
影响因子：
8.4
通讯作者：
Yoon, Juyoung
中科院分区：
文献类型：
--
作者：
Chen, Liyan;Wu, Di;Yoon, Juyoung
由于这种气体递质在各种生理和病理过程中发挥着关键作用，开发简单且选择性的荧光探针来检测一氧化氮（NO）具有重要意义。尽管迄今为止已经开发了大量的 NO 荧光探针，但只有少数显示出比率荧光变化。在本研究中，开发了一种基于激发态分子内质子转移 (ESIPT) 荧光团的 NO 比率荧光探针。与其他相关分析物相比，该探针对 NO 表现出良好的选择性和灵敏度。此外，该探针还应用于活细胞中NO的成像。 (C) 2017 Elsevier B.V. 保留所有权利。
Development of simple and selective fluorescence probes for the detection of nitric oxide (NO) is of great important because of the key roles this gasotransmitter plays in various physiological and pathological processes. Although a large number of fluorescence probes for NO have been developed thus far, only a few display ratiometric fluorescence changes. In this study, an excited-state intramolecular proton transfer (ESIPT) fluorophore based, ratiometric fluorescence probe for NO was developed. The probe shows good selectivity and sensitivity for NO over other relevant analytes. Furthermore, the probe was applied to imaging NO in living cells. (C) 2017 Elsevier B.V. All rights reserved.