A simple method for measuring zinc absorption in man using a short-lived isotope (69mZn).
A simple method for measuring zinc absorption in man using a short-lived isotope (69mZn).
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一种使用短寿命同位素 (69mZn) 测量人体锌吸收量的简单方法。
DOI：
10.1093/ajcn/33.4.881
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
L. Turnberg
中科院分区：
文献类型：
--
作者：
M. Molokhia;G. Sturniolo;R. Shields;L. Turnberg
使用半衰期为13.9小时的短寿命锌同位素（69 mZn），我们开发了一种简单的锌吸收试验。口服同位素（50 μ Ci）和2 mg元素锌后，从连续8小时采集的血样中测定的放射性构建血浆外观曲线。两周后静脉注射同位素（25 μ Ci），构建血浆消失曲线。通过使用去卷积程序对出现和消失曲线进行计算机分析来计算吸收。5名正常受试者的平均吸收率为61%（范围为41 - 79%）。在三名受试者给予食物，或1小时前的同位素，吸收被延迟，并减少到小于20%的口服剂量在8小时。这种测试锌的吸收是简单的执行，因为同位素有一个短的半衰期，具有的优势，使患者只受到有限的辐射。
Using a short-lived isotope of zinc (69mZn) with a half-life of 13.9 hr, we have developed a simple test of zinc absorption. After an oral dose of isotope (50 muCi) with 2 mg of elemental zinc a plasma appearance curve was constructed from radioactivity determined in blood samples taken sequentially over 8 hr. Two week later an iv dose of isotope (25 muCi) was administered and a plasma disappearance curve was constructed. Absorption was calculated by computer analysis of appearance and disappearance curves using a deconvolution programme. Mean absorption in five normal subjects was 61% (range 41 to 79%). In three subjects given food with, or 1 hr before the isotope, absorption was delayed and reduced to less than 20% of the oral dose at 8 hr. This test of zinc absorption is simple to perform and, because the isotope has a short half-life, has the advantage of subjecting patients to only limited radiation.