COVID-19 infection in 10 common variable immunodeficiency patients in New York City.
COVID-19 infection in 10 common variable immunodeficiency patients in New York City.
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DOI：
10.1016/j.jaip.2020.11.006
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Eisenberg R
中科院分区：
文献类型：
--
作者：
Cohen B;Rubinstein R;Gans MD;Deng L;Rubinstein A;Eisenberg R
常见变异型免疫缺陷（CVID）是最常见的体液免疫缺陷，其特征是低丙种球蛋白血症、疫苗反应受损和复发性鼻窦肺部感染。 1 尽管已知的更严重 COVID-19 感染的危险因素包括年龄较大、高血压 (HTN)、肥胖和心血管疾病，2 免疫功能低下患者与 COVID-19 感染严重程度之间的关系尚未明确。研究特定的免疫功能低下人群可能会明确这些患者因感染 COVID-19 而发病和死亡的风险。 Quinti 等人的一个病例系列描述了 4 名 CVID 患者和 2 名无丙种球蛋白血症患者，除一名外，其余患者均已康复，这表明死亡率可能与普通人群相似。在这里，我们评估了我们中心的一组 CVID 患者的感染严重程度、住院需要和死亡率。这项回顾性研究在蒙特菲奥里医学中心进行，并得到纽约布朗克斯阿尔伯特爱因斯坦医学院机构审查委员会的批准。 Clinical Look Glass (CLG) 是一个从电子病历中检索数据的程序，用于识别患有低丙种球蛋白血症或 CVID 国际疾病分类代码的患者。进行了手动图表审查，如果患者符合 2016 年国际共识文件 CVID 诊断标准，则将其纳入队列。 1 排除患有其他原发性或继发性免疫缺陷的患者。
Common variable immunodeficiency (CVID), the most prevalent humoral immunodeficiency, is characterized by hypogammaglobulinemia, impaired vaccine responses, and recurrent sinopulmonary infections. 1 Although known risk factors for more severe COVID-19 infection include older age, hypertension (HTN), obesity, and cardiovascular disease, 2 the association of immunocompromised patients and severity of COVID-19 infection is not well established. Studying specific immunocompromised cohorts may clarify risk of morbidity and mortality to these patients from COVID-19 infection. A case series by Quinti et al3 described 4 patients with CVID and 2 with agammaglobulinemia, all of whom recovered except one, suggesting perhaps a similar mortality to the general population. Here, we assess the severity of infection, need for hospitalization, and mortality in a cohort of patients with CVID at our center. This retrospective study was conducted at Montefiore Medical Center and approved by the institutional review board at the Albert Einstein College of Medicine in Bronx, NY. Clinical Looking Glass (CLG), a program that retrieves data from the electronic medical record, was used to identify patients with hypogammaglobulinemia or CVID International Classification of Diseases code. A manual chart review was performed, and patients were included in the cohort if they met International Consensus Document 2016 diagnostic criteria for CVID. 1 Patients with other primary or secondary immunodeficiency were excluded.
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DOI：
10.1016/j.jaip.2015.07.025
发表时间：
2016-01
期刊：
The journal of allergy and clinical immunology. In practice
影响因子：
--
作者：
Bonilla FA;Barlan I;Chapel H;Costa-Carvalho BT;Cunningham-Rundles C;de la Morena MT;Espinosa-Rosales FJ;Hammarström L;Nonoyama S;Quinti I;Routes JM;Tang ML;Warnatz K
通讯作者：
Warnatz K
影响因子：
16.1
作者：
Vizcarra, Pilar;Perez-Elias, Maria J.;Casado, Jose L.
通讯作者：
Casado, Jose L.
影响因子：
14.2
作者：
Quinti, Isabella;Lougaris, Vassilios;Plebani, Alessandro
通讯作者：
Plebani, Alessandro
影响因子：
4.4
作者：
Soresina, Annarosa;Moratto, Daniele;Badolato, Raffaele
通讯作者：
Badolato, Raffaele
影响因子：
20.3
作者：
Treon, Steven P.;Castillo, Jorge J.;Yang, Guang
通讯作者：
Yang, Guang