S-100 PROTEIN IN HUMAN CHONDROCYTES
S-100 PROTEIN IN HUMAN CHONDROCYTES
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DOI：
10.1038/295063a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
ARNASON, BGW
中科院分区：
文献类型：
--
作者：
STEFANSSON, K;WOLLMANN, RL;ARNASON, BGW
胎儿颅骨和内脏软骨中的软骨细胞被认为来自神经嵴，而身体其他部位的软骨细胞被认为来自中胚层软骨细胞。鸡胚盆腔软骨细胞是已知的唯一非神经外胚层来源的对神经生长因子有反应的细胞。此外，鸡的胚胎脊髓和神经视网膜可合成II型胶原蛋白5,6，这种胶原蛋白最初被认为局限于软骨。在这里，我们报道了S-100蛋白（S-100）在人类胎儿的头骨、椎骨、肋骨、胸骨、喉部和长骨的软骨细胞以及成人的喉部和剑突中的存在。中胚层软骨细胞是唯一含有S-100但不被认为起源于神经外胚层的细胞，因此我们的结果表明这些软骨细胞可能比传统认为的更接近神经外胚层。
Chondrocytes in the fetal skull and visceral cartilage are considered to be of neural crest origin1while those found elsewhere in the body are thought to be derived from mesoderm2,3(mesodermal chondrocytes). Chondrocytes of pelvic rudiments from chick embryos are the only cells known to respond to nerve growth factor that are not of neuroectodermal origin4. In addition, embryonic spinal cord5and neural retina6of chickens synthesize type II collagen5,6, originally thought to be confined to cartilage. Here we report the presence of the S-100 protein (S-100) in chondrocytes of skull, vertebrae, ribs, sternum, larynx and long bones of the human fetus, and larynx and xiphoid process of the human adult. Mesodermal chondrocytes are the only cells which contain S-100 and yet are not considered to be of neuroectodermal origin, thus our results indicate that these chondrocytes may be developmentally closer to neuroectoderm than traditionally thought.