Detecting Antibody-Antigen Interactions with Chiral Plasmons: Factors Influencing Chiral Plasmonic Sensing
Detecting Antibody-Antigen Interactions with Chiral Plasmons: Factors Influencing Chiral Plasmonic Sensing
复制标题
检测抗体-抗原与手性等离子体激元的相互作用：影响手性等离子体传感的因素
DOI：
10.1002/adpr.202100155
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Koyroytsaltis-McQuire D
中科院分区：
文献类型：
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作者：
Koyroytsaltis-McQuire D
由光与（手性）纳米结构相互作用产生的具有增强的不对称性（超手性）的手性近场，可能为生物物理应用的新型传感和计量技术提供一条途径。然而，这些近场导致手性介质检测的机制仍然知之甚少。通过对抗体-抗原范例系统进行数值建模和实验测量相结合，说明了影响手性传感功效的重要因素。结果表明，局域和晶格手性共振表现出对映体敏感性。然而，只有局部共振表现出对检测到的手性介质结构的强烈依赖性。这可以归因于双折射手性层能够通过充当光学手性的接收器/源来强烈改变近场的性质，从而改变纳米结构元件之间的电感耦合。此外，值得注意的是，表面形态/缺陷可以通过介导感应耦合来增强局域手性等离子体模式的传感能力。
Chiral near fields possessing enhanced asymmetry (superchirality), created by the interaction of light with (chiral) nanostructures, potentially provide a route to novel sensing and metrology technologies for biophysical applications. However, the mechanisms by which these near fields lead to the detection of chiral media is still poorly understood. Using a combination of numerical modeling and experimental measurements on an antibody–antigen exemplar system, important factors that influence the efficacy of chiral sensing are illustrated. It is demonstrated that localized and lattice chiral resonances display enantiomeric sensitivity. However, only the localized resonances show a strong dependency on the structure of the chiral media detected. This can be attributed to the ability of birefringent chiral layers to strongly modify the properties of near fields by acting as a sink/source of optical chirality, and hence alter inductive coupling between nanostructure elements. In addition, it is highlighted that surface morphology/defects may amplify sensing capabilities of localized chiral plasmonic modes by mediating inductive coupling.