Serum Levels of Insulin-Like Growth Factor-I Are Positively Associated with Functional Outcome After Hip Fracture in Elderly Women
Serum Levels of Insulin-Like Growth Factor-I Are Positively Associated with Functional Outcome After Hip Fracture in Elderly Women
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DOI：
10.1097/phm.0b013e31818e002d
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发表时间：
2009-02-01
影响因子：
3
通讯作者：
Cavanna, Alberto
中科院分区：
文献类型：
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作者：
Di Monaco, Marco;Vallero, Fulvia;Cavanna, Alberto
目的：调查髋部骨折女性血清胰岛素样生长因子-I (IGF-I) 水平与功能结果之间的关联设计：我们调查了 188 名髋部骨折后连续住进康复医院的女性中的 171 名。骨折发生后 21.3 +/- 6.1 天（平均值 +/- SD）通过自动化学发光免疫测定法评估 IGF-I 血清水平。使用 Barthel 指数评分评估功能结果。 结果：在 Spearman 等级检验中，我们观察到 IGF-I 水平与住院康复出院时的 Barthel 指数评分（rho = 0.213；P = 0.005）以及康复期间 Barthel 指数评分的变化（rho = 0.222；P = 0.004）之间存在显着正相关。在多元回归中，在调整了一些潜在的混杂因素（包括年龄、认知障碍、压疮、神经功能障碍、感染、康复入院时的 Barthel 指数评分和住院时间）后，发现 IGF-I 与功能评分及其在康复期间的变化之间存在显着相关性（P < 0.05）。总体而言，这组预后因素占功能评分方差的 55% 和康复期间其变化的方差的 31%。结论：IGF-I 血清水平与女性髋部骨折后的功能能力显着相关。
Objective: To investigate the association between serum levels of insulin-like growth factor-I (IGF-I) and functional outcome in hip-fracture womenDesign: We investigated 171 of 188 women admitted consecutively to a rehabilitation hospital after hip fracture. IGF-I serum levels were assessed by using an automated chemiluminescence immunoassay 21.3 +/- 6.1 days (mean +/- SD) after fracture occurrence. Functional outcome was assessed using Barthel index scores.Results: At a Spearman rank test we observed a significant positive correlation between IGF-I levels and both Barthel index scores at discharge from inpatient rehabilitation (rho = 0.213; P = 0.005) and changes in Barthel index scores during rehabilitation (rho = 0.222; P = 0.004). At multiple regression, a significant association between IGF-I and both functional scores and their changes during rehabilitation was found after adjustment for several potential confounders, including age, cognitive impairment, pressure ulcers, neurologic impairment, infections, Barthel index score at admission to rehabilitation, and length of stay in hospital (P < 0.05). Overall, the panel of prognostic factors accounted for 55% of the variance in the functional score and 31% of the variance in its change during rehabilitation.Conclusions: IGF-I serum levels were significantly associated with ability to function after hip fracture in women.