A Voxel-Based Magnetic Resonance Imaging Morphometric Study of Cerebral and Cerebellar Gray Matter in Patients Under 65 Years with Essential Tremor.
A Voxel-Based Magnetic Resonance Imaging Morphometric Study of Cerebral and Cerebellar Gray Matter in Patients Under 65 Years with Essential Tremor.
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DOI：
10.12659/msm.906437
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发表时间：
2018-05-13
期刊：
影响因子：
--
通讯作者：
Yang X
中科院分区：
文献类型：
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作者：
Cao H;Wang R;Luo X;Li X;Hallett M;Thompson-Westra J;Yang J;Qu Q;Yang X
本研究的目的是使用功能磁共振成像 (fMRI) 和基于体素的形态测量 (VBM) 分析，比较 60 岁以下特发性震颤患者与年龄匹配和性别匹配的正常健康志愿者对照受试者的大脑和小脑灰质的形态变化。一项回顾性、对照、比较临床研究包括 17 名年龄<60 岁的特发性震颤患者以及 17 名年龄匹配和性别匹配的健康志愿者对照受试者，这些受试者在 2010 年 6 月至 2012 年 7 月期间招募。MRI 和 VBM 分析用于比较各组之间的大脑和小脑灰质密度。使用华盛顿高地-因伍德特发性震颤遗传研究 (WHIGET) 评定量表来评估患者组震颤的严重程度。记录所有研究参与者的临床和人口特征。 MRI和VBM分析显示特发性震颤患者小脑、枕叶梭状皮质、右颞下回和中央前叶双侧显着扩张（P<0.005）；左顶叶灰质减少。感兴趣区域（ROI）分析显示丘脑、中脑和楔前叶体积增大（P<0.005）。灰质变化与临床变量（包括年龄、性别、震颤持续时间、日常生活能力（ADL）量表、简易精神状态检查（MMSE）量表、家族史和震颤严重程度）的变化之间没有显着相关性。 60岁以下的特发性震颤患者的小脑灰质扩张主要可能是小脑功能下降代偿的结果。
The aim of this study was to compare the morphological changes in cerebral and cerebellar gray matter in patients with essential tremor under 60-years-of-age, with age-matched and gender-matched normal healthy volunteer control subjects, using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM) analysis. A retrospective, controlled, comparative clinical study included 17 patients with essential tremor, <60 years-of-age, and 17 age-matched and gender-matched healthy volunteer control subjects, recruited between June 2010–July 2012. MRI and VBM analysis were used to compare cerebral and cerebellar gray matter density between groups. The Washington Heights–Inwood Genetic Study of Essential Tremor (WHIGET) rating scale was used to assess tremor severity in the patient group. Clinical and demographic characteristics were recorded for all study participants. MRI and VBM analysis showed significant bilateral expansion of the cerebellum, occipital fusiform cortices, right inferior temporal gyrus, and precentral lobes in patients with essential tremor (P<0.005); reduction in gray matter was found in the left parietal lobe. The region of interest (ROI) analysis showed volume enlargement in the thalamus, midbrain, and the precuneus (P<0.005). No significant correlation between changes in gray matter and changes in clinical variables, including age, gender, tremor duration, the activity of daily living (ADL) scale, the mini-mental state examination (MMSE) scale, family history, and tremor severity were found. Predominantly cerebellar gray matter expansion in patients less than 60 years-of-age with essential tremor might be the result of compensation for the decline in cerebellar function.