Regulation of membrane-bound enzymes of glycosphingolipid biosynthesis
Regulation of membrane-bound enzymes of glycosphingolipid biosynthesis
复制标题
鞘糖脂生物合成膜结合酶的调节
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
C.
中科院分区：
文献类型：
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作者：
D.;M. R.;C.
在过去的十年中，随着质谱、核磁共振和单克隆抗体技术等灵敏分析方法的应用，鞘糖脂生物化学的描述阶段蓬勃发展。因此，对细胞表面表达的复杂碳水化合物结构之间相互关系的认识，将注意力集中在对负责这种多样性的糖基化酶的调节上。本文综述了糖基转移酶的区隔调控和直接脂质环境的影响等几个潜在的调控分子机制；受体底物、二价阳离子和核苷酸可用性对酶活性的调节；酶操纵子的修饰是由病毒转化整合位点引起的，或者由磷酸化和去磷酸化引起的，这两种修饰目前处于鞘糖脂研究的前沿。B . d .， J. d .， R. M. Soltysiak， C. C. Sweeley。鞘糖脂生物合成膜结合酶的调控。[j] .油脂杂志。1984。25日:1541 - 1547。
Abatract T h e descriptive phase of glycosphingolipid biochemistry has blossomed over the past decade with the application of exquisitely sensitive analytical methods of mass spectrometry, NMR, and monoclonal antibody technology. Consequently, appreciation of the interrelation among the complex carbohydrate structures that are expressed on the cell surface has focused attention on the regulation of the glycosyltmnferases responsible for such diversity. This review explores some aspects of several potential molecular mechanisms of regulation-compartmentation of glycosyltransferases and effect of the immediate lipid environment; modulation of enzyme activity by acceptor substrate, divalent cations, and availability of sugar nucleotides; modifications of the enzyme operon elicited by viral transformation integration sites, or to the enzyme by phosphorylationdephosphorylation-which are presently at the cutting edge of glycosphingolipid s c i e n c e . B u d , J. D., R. M. Soltysiak, and C. C. Sweeley. Regulation of membranebound enzymes of glycosphingolipid biosynthesis. J. Lipid Res. 1984. 25: 1541-1547.