Implementation and application of a brain template for multiple volumes of interest
Implementation and application of a brain template for multiple volumes of interest
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DOI：
10.1002/hbm.10016
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发表时间：
2002-03-01
影响因子：
4.8
通讯作者：
Duncan, J
中科院分区：
文献类型：
--
作者：
Hammers, A;Koepp, MJ;Duncan, J
我们提出了一个区域模板和一个协议，用于转换该模板，以定义解剖体积的利益（VOIs）在人脑中没有操作员的干预，基于软件中包含的SPM 99包（统计参数映射，威康认知神经学系，伦敦，英国）。我们使用参考大脑的MRI来创建覆盖整个大脑的41个VOI的解剖模板，这些模板可以在空间上进行转换以适应单个大脑扫描。修改后的软件允许对转换后的模板进行重新切片和调整，以适应任何类型的共配准功能数据。可以添加单独定义的VOI。我们提出了一个必要的空间变换的评估，并比较在两个不同的方向获得的扫描结果。为了评估空间转换，选择了分布在整个大脑中的11个标志。对所有标志处的每个标志处重复样本之间的欧几里得距离取平均值，得到1.3 +/- 1.0 mm的平均差异。标志之间的平均欧几里得距离（MRI：转换模板）在前后连合（ACPC）中为8.1 +/- 3.7 mm，在颞叶（TL）方向中为7.6 +/- 3.7 mm。在本研究中，我们使用[（11）C]-氟马西尼-（FMZ-）PET作为应用的区域模板的例子。34名健康志愿者进行了扫描，21名在标准ACPC方向，13名在TL方向。所有患者均接受了高分辨率MRI和FMZ-PET检查。皮质区域FMZ结合的平均变异系数（CV）为0.15，与手动定义VOI的CV相当。在不同方向获得的对照组中，FMZ结合在6/19个解剖区域中存在显著差异，可能是由于各向异性体素尺寸。这个新模板允许可靠和快速地定义多个VOI。它可以用于不同的成像模式和不同的方向。需要在相同的方向上采集比较组的成像数据。Hum.脑图谱15：165- 174，2002. (C)2002 Wiley-Liss，Inc.
We present a region template and a protocol for transforming that template to define anatomical volumes of interest (VOIs) in the human brain without operator intervention, based on software contained in the SPM99 package (Statistical Parametric Mapping, Wellcome Department of Cognitive Neurology, London, UK). We used an MRI of a reference brain to create an anatomical template of 41 VOIs, covering the entire brain, that can be spatially transformed to fit individual brain scans. Modified software allows for the reslicing and adaptation of the tranformed template to any type of coregistered functional data. Individually defined VOIs can be added. We present an assessment of the necessary spatial transformations and compare results obtained for scans acquired in two different orientations. To evaluate the spatial transformations, 11 landmarks distributed throughout the brain were chosen. Euclidean distances between repeat samples at each landmark were averaged across all landmarks to give a mean difference of 1.3 +/- 1.0 mm Average Euclidean distances between landmarks (MRI:transformed template) were 8.1 +/- 3.7 mm in anterior-posterior commissure (ACPC) and 7.6 +/- 3.7 mm in temporal lobe (TL) orientation. In this study, we use [(11)C]-flumazenil-(FMZ-)PET as an example for the application of the region template. Thirty-four healthy volunteers were scanned, 21 in standard ACPC orientation, 13 in TL orientation. All had high resolution MRI and FMZ-PET. The average coefficient of variation (CV) of FMZ binding for cortical regions was 0.15, comparable with CVs from manually defined VOIs. FMZ binding was significantly different in 6/19 anatomical areas in the control groups obtained in the different orientations, probably due to anisotropic voxel dimensions. This new template allows for the reliable and fast definition of multiple VOIs. It can be used for different imaging modalities and in different orientations. It is necessary that imaging data for groups compared are acquired in the same orientation. Hum. Brain Mapping 15:165-174,2002. (C) 2002 Wiley-Liss, Inc.