Q&A: What are exosomes, exactly?
Q&A: What are exosomes, exactly?
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DOI：
10.1186/s12915-016-0268-z
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发表时间：
2016-06-13
期刊：
影响因子：
5.4
通讯作者：
Edgar JR
中科院分区：
文献类型：
--
作者：
Edgar JR
外泌体是30年前首次描述的细胞外囊泡，此后参与细胞间通讯和疾病状态的传播，并作为药物发现的一种手段进行探索。然而，关于它们生物学的基本问题仍然没有答案。在这里，我探讨了什么是外泌体，强调了研究它们的困难，并解释了目前的定义和外泌体生物学中的一些悬而未决的问题。
Exosomes are extracellular vesicles first described as such 30 years ago and since implicated in cell–cell communication and the transmission of disease states, and explored as a means of drug discovery. Yet fundamental questions about their biology remain unanswered. Here I explore what exosomes are, highlight the difficulties in studying them and explain the current definition and some of the outstanding issues in exosome biology.