A balancing act for autophagin.
A balancing act for autophagin.
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DOI：
10.1172/jci43238
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发表时间：
2010-07
期刊：
影响因子：
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通讯作者：
A. Till;S. Subramani
中科院分区：
文献类型：
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作者：
A. Till;S. Subramani
自噬是一种受到严格调节的分解代谢过程，细胞通过降解其成分来处理不需要的细胞质元素并回收细胞重塑所需的营养物质。哺乳动物自噬的研究引起了人们极大的兴趣，因为它与一系列生理和病理状态有关。在本期《JCI》中，Mariño等人揭示了自噬在与内耳病理相关的平衡障碍中的作用。缺乏蛋白酶自噬相关的4B （Atg4b，也称为自噬素-1）的小鼠表现出自噬的系统性减少，并且在耳蜗的发育中表现出缺陷，耳蜗是含有碳酸钙晶体和蛋白质的有机颗粒，对哺乳动物的平衡感知（平衡感觉）至关重要。这项工作的有趣之处在于，自噬阻滞会损害耳锥体蛋白的分泌和组装，强调自噬在不同于大分子降解的功能中的作用。
Autophagy is a tightly regulated catabolic process whereby cells degrade their constituents to dispose of unwanted cytoplasmic elements and recycle nutrients for cellular remodeling. Studies of autophagy in mammals have elicited substantial interest because it is linked to a range of physiologic and pathologic states. In this issue of the JCI, Mariño et al. uncover a role for autophagy in a balance disorder related to inner ear pathologies. Mice lacking the protease autophagy-related 4B (Atg4b, also known as autophagin-1) exhibited a systemic reduction in autophagy and showed defects in the development of otoconia, organic particles that contain calcium carbonate crystals and proteins and that are essential for balance perception (equilibrioception) in mammals. The intriguing aspect of this work is that an autophagy block impairs the secretion and assembly of otoconial proteins, emphasizing a role for autophagy in functions distinct from macromolecule degradation.