HISTOGENESIS OF THE LIVER ^ †
HISTOGENESIS OF THE LIVER ^ †
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肝脏的组织发生^ †
DOI：
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发表时间：
1963
影响因子：
5.2
通讯作者：
E. Leduc
中科院分区：
文献类型：
--
作者：
J. W. Wilson;Cynthia S. Groat;E. Leduc
在传统的描述中，肝的原基来自于许多来源：（1）前肠底部的内胚层（图1和2），其供应实质细胞和胆汁引流系统的细胞，包括胆管、胆管和胆囊;（2）横隔的间充质，在某些分类群中，来自体腔内邻近的间皮层的特殊间充质也有贡献，其供应Glisson囊的结缔组织和一些造血组织;（3）穿过横隔的主要血管的衬里，其供应窦状隙的衬里细胞;和（4）卵黄囊的血岛，其通过接种供应部分造血组织。来自前肠的内胚层憩室迅速穿透横隔，横隔基本上是卵黄静脉及其周围的间充质，位于内脏片的两层之间，即，在一侧的卵黄柄内胚层和前肠之间，在另一侧的内脏中胚层形成体腔的中皮层。当憩室中的细胞束与隔膜中的静脉接触时，会发生相互渗透，米诺托称之为交叉。这导致由海绵状软组织组成的肿块，其空间被窦网络占据。这些窦状隙起初较宽，但随着实质相对数量的增加，最终会变窄形成肝窦。
In the conventional description the anlage of the liver arises from a number of sources: ( 1 ) the endoderm of the floor of the foregut (FIGURES 1 and 2 ) which supplies the parenchymal cells and the cells of the bile drainage system, including the bile ducts, cholangioles, and gallbladder; (2) the mesenchyme of the septum transversum with, in some taxonomic groups, a contribution of a special mesenchyme derived from the adjacent mesothelial lining of the coelomic cavity, which supplies the connective tissue of Glisson’s capsule and some of the hematopoeic tissue; ( 3 ) the lining of the major blood vessels that traverse the septum transversum, which supplies the lining cells of the sinusoids; and (4) the blood islands of the yolk sac which, by seeding, supply part of the hematopoeic tissue. The endodermal diverticulum from the foregut rapidly penetrates the septum transversum which is, essentially, the vitelline veins with their surrounding mesenchyme between the two layers of the splanchnopleure, i.e., between the endoderm of the yolk stalk and the foregut on one side, and on the other, the splanchnic mesoderm which forms the mesothelium of the coelom. As the strands of the cells from the diverticulum come into contact with the veins in the septum there is a mutual interpenetration, that Minotl called intercressence. This results in a mass composed of a spongework of parenchyma with the spaces occupied by a network of sinuses. These are at first wide, but will eventually narrow to form the sinusoids of the definitive liver as the relative amount of parenchyma increases.