Sclerosing odontogenic carcinoma presenting on the hard palate of a 43-year-old female: a case report
Sclerosing odontogenic carcinoma presenting on the hard palate of a 43-year-old female: a case report
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DOI：
10.1016/j.oooo.2016.07.009
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发表时间：
2016-12-01
影响因子：
2.9
通讯作者：
Conn, Brendon I.
中科院分区：
文献类型：
--
作者：
Wood, Andrew;Young, Fiona;Conn, Brendon I.
我们报告一位43岁女性硬颚发生硬化性牙源性癌的病例。肿瘤表现为无症状的硬肿，组织病理学特征为广泛分布的巢和透明化胶原纤维之间浸润的淡细胞索。注意到明显的神经周围和神经内侵犯和骨侵蚀。肿瘤细胞用泛细胞角蛋白（PanCK）、细胞角蛋白19（CK 19）、细胞角蛋白5/6（CK 5/6）、细胞角蛋白14（CK 14）、p63和E-钙粘蛋白的抗体染色，但用癌胚抗原（CEA）、细胞角蛋白7（CK 7）、细胞角蛋白20（CK 20）、雌激素受体（ER）、孕激素受体（PR）或S100的抗体不染色。用阿辛蓝/高碘酸-希夫染色法和酶法对粘蛋白染色结果不明确，没有明确的粘蛋白或粘蛋白的证据。经切口活检初步诊断为腺癌NOS，突出的锉样和胞浆空泡化提示首先考虑转移性乳腺癌。经过分期调查和手术切除后，肿瘤的真实性质变得清晰。患者仅接受手术治疗，17个月后无疾病。
We present a case of sclerosing odontogenic carcinoma (SOC) occurring on the hard palate of a 43-year-old female. The tumor presented as an asymptomatic firm swelling and histopathologically was characterized by widely dispersed nests and cords of bland cells infiltrating between hyalinized collagen fibers. Prominent perineural and intraneural invasion and erosion of bone was noted. The tumor cells showed staining with antibodies to pan-cytokeratin (PanCK), cytokeratin 19 (CK19), cytokeratin 5/6 (CK5/6), cytokeratin 14 (CK14), p63 and E-cadherin, but no staining with antibodies to carcinoembryonic antigen (CEA), cytokeratin 7 (CK7), cytokeratin 20 (CK20), estrogen receptor (ER), progesterone receptor (PR) or S100. Staining for mucin with alcian blue/periodic acid-Schiff with diastase was equivocal, with no definite evidence of mucin or muciphages. An initial diagnosis of adenocarcinoma NOS was made upon incisional biopsy, with the prominent filing pattern and cytoplasmic vacuolization prompting consideration of metastatic breast cancer in the first instance. The true nature of the tumor became clear after staging investigations and surgical resection. The patient was treated by surgery alone and is disease-free after 17 months.