Noninfectious vesicular stomatitis virus particles deficient in the viral nucleocapsid
Noninfectious vesicular stomatitis virus particles deficient in the viral nucleocapsid
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缺乏病毒核衣壳的非传染性水泡性口炎病毒颗粒
DOI：
10.1128/jvi.29.2.443-447.1979
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发表时间：
1979
影响因子：
5.4
通讯作者：
H. Lodish
中科院分区：
文献类型：
--
作者：
T. Schnitzer;H. Lodish
在互补组III中，水疱性口炎病毒的几个温度敏感突变体在不允许的温度下产生非感染性颗粒，其中含有病毒M(基质)和G(糖蛋白)蛋白，但不到正常比例的N蛋白或RNA的10%。由于第三组突变株被认为是病毒M蛋白结构基因的缺陷，这些发现表明M蛋白与核衣壳之间的相互作用在病毒萌发过程中是重要的。综合之前的研究结果，他们认为M是花蕾形成的关键蛋白质。
Several temperature-sensitive mutants of vesicular stomatitis virus in complementation group III produce, at nonpermissive temperature, noninfectious particles which contain the viral M (matrix) and G (glycoprotein) proteins but less than 10% of the normal proportion of N protein or RNA. Since group III mutants are thought to be defective in the structural gene for the virus M protein, these findings demonstrate that an interaction between M and the nucleocapsid is of importance in virus budding. Taken together with earlier results, they suggest that M is the key protein in bud formation.