Beneficial Effect of Physical Training on Blood Flow to Myocardium Perfused by Chronic Collaterals in the Exercising Dog
Beneficial Effect of Physical Training on Blood Flow to Myocardium Perfused by Chronic Collaterals in the Exercising Dog
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体能训练对运动犬慢性络脉灌注心肌血流的有益影响
DOI：
10.1161/01.cir.57.3.575
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发表时间：
1978
期刊：
影响因子：
37.8
通讯作者：
S. Epstein
中科院分区：
文献类型：
--
作者：
W. H. Heaton;K. Marr;N. Capurro;R. Goldstein;S. Epstein
摘要：为了确定体育训练对侧支血流的影响，我们在14只慢性冠状动脉闭塞病变的狗的休息和运动期间，通过注射15个放射性微球来测量局部心肌血流量（MBF）。7只狗随后接受了6周的训练，而其他7只狗则留在狗窝里。训练效果通过运动期间平均每分钟35次的心率下降来证明。6周后重复MBF研究。心肌样本取自正常灌注区（NZ）和经络供血区（络依赖区或CZ）。运动时CZ的心内膜血流量平均为1.36 ml/min/g (NZ的69%，P < 0.05)，表明相对灌注不足。NZ和CZ心外膜血流量相等。6周后，对照组动物的MBF无明显变化。然而，训练后，运动期间CZ心内膜灌注不足的MBF比训练前增加39%。CZ心外膜部分（未表现出灌注不足）在训练后的运动中没有表现出MBF的变化。我们的数据表明，冠心病训练的有益效果可能包括改善心肌欠灌注侧支依赖部分的MBF。
SUMMARYTo determine the effect of physical training on collateral blood flow, we measured regional myocardial blood flow (MBF) by injecting 15 A radioactive microspheres at rest and during exercise in 14 dogs with chronic coronary occlusive lesions. Seven dogs subsequently trained for 6 weeks while the other seven remained in kennels. Training effect was documented by decrease in heart rate during exercise that averaged 35 beats/min. MBF studies were repeated after 6 weeks. Myocardial samples were obtained from normally perfused zones (NZ) and from regions supplied via collaterals (collateral dependent zones or CZ). Initially, endocardial blood flow in CZ averaged 1.10 ml/min/g (83% of NZ, P < 0.05) at rest and 1.36 ml/min/g (69% of NZ, P < 0.05) during exercise, indicating relative underperfusion. Epicardial blood flow was equal in NZ and CZ. After 6 weeks MBF was not significantly changed in control animals. After training, however, MBF to underperfused endocardium of CZ during exercise was 39% greater than it had been prior to training. The epicardial portion of CZ (not exhibiting underperfusion) showed no change in MBF during exercise after training.Our data suggest that beneficial effects of training in coronary disease may include improvement in MBF to underperfused collateraldependent portions of myocardium.