"On-Off" Switching of Dynamically Controllable Self-Assembly Formation of Double-Responsive Block Copolymers with Tunable LCSTs
"On-Off" Switching of Dynamically Controllable Self-Assembly Formation of Double-Responsive Block Copolymers with Tunable LCSTs
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DOI：
10.1002/pola.24226
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发表时间：
2010-10
期刊：
影响因子：
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通讯作者：
Youhei Kotsuchibashi;Youhei Kotsuchibashi;Youhei Kotsuchibashi;M. Ebara;Kazuya Yamamoto;T. Aoyagi;T. Aoyagi;T. Aoyagi
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文献类型：
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作者：
Youhei Kotsuchibashi;Youhei Kotsuchibashi;Youhei Kotsuchibashi;M. Ebara;Kazuya Yamamoto;T. Aoyagi;T. Aoyagi;T. Aoyagi
我们在这里报告了一个可逆的自组装形成系统使用嵌段共聚物与热调谐性能。采用原子转移自由基聚合法，通过单体顺序加成，合成了一系列具有两个低临界溶液温度的双响应嵌段共聚物：聚（N-异丙基丙烯酰胺（NIPAAm））-嵌段-聚（NIPAAm-co-N-（异丁氧基甲基）丙烯酰胺（BMAAm））。当在室温下溶解于水溶液中时，嵌段共聚物保持单异构。在高于室温加热时，嵌段共聚物自组装成胶束结构。通过改变BMAAm含量来控制胶束形成温度和所得直径。1H核磁共振，动态光散射，场发射扫描电子显微镜和荧光光谱揭示了单分散纳米组装体的存在，并证明组装体形成/反转过程是完全可逆的。此外，一个模型的疏水分子，芘，成功地装载到胶束核心包括芘在原来的聚合物溶液。进一步加热导致介观胶束聚集和沉淀。这种双胶束和聚集系统将发现在药物递送应用中的效用，因为热触发允许疏水药物的水负载和它们随后的释放。© 2010 Wiley Periodicals，Inc. J Polym Sci A部分：Polym Chem，2010
We report here a reversible self-assembly formation system using block copolymers with thermo-tunable properties. A series of double-responsive block copolymers, poly(N-isopropylacrylamide (NIPAAm))-block-poly(NIPAAm-co-N-(isobutoxymethyl)acrylamide (BMAAm)) with two lower critical solution temperatures were synthesized by one-pot atom transfer radical polymerization via sequential monomer addition. When dissolved in aqueous solution at room temperature, the block copolymers remained unimeric. Upon heating above room temperature, the block copolymers self-assembled into micellar structures. The micelle formation temperature and the resulting diameter were controlled by varying the BMAAm content. 1H Nuclear Magnetic Resonance, dynamic light scattering, field-emission scanning electron microscopy, and fluorescence spectra revealed the presence of a monodisperse nanoassembly, and demonstrated the assembly formation/inversion process was fully reversible. Moreover, a model hydrophobic molecule, pyrene, was successfully loaded into the micelle core by including pyrene in the original polymer solution. Further heating resulted in mesoscopic micelle aggregation and precipitation. This dual micelle and aggregation system will find utility in drug delivery applications as a thermal trigger permits both aqueous loading of hydrophobic drugs and their subsequent release. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010