A voxel-based morphometry comparison of the 3.0T ADNI-1 and ADNI-2 volumetric MRI protocols.
A voxel-based morphometry comparison of the 3.0T ADNI-1 and ADNI-2 volumetric MRI protocols.
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3.0T ADNI-1 和 ADNI-2 体积 MRI 协议基于体素的形态测量比较。
DOI：
10.1002/gps.4179
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发表时间：
2015-05
影响因子：
4
通讯作者：
Simmons, Andrew
中科院分区：
文献类型：
--
作者：
Brunton, Simon;Gunasinghe, Cerisse;Jones, Nigel;Kempton, Matthew J.;Westman, Eric;Simmons, Andrew
阿尔茨海默病神经影像倡议3.0T MRI图像采集方案在原始ADNI-1资助和随后的两个赠款（ADNI-GO和ADNI-2）之间发生了变化。本研究的目的是使用基于体素的形态测定法（VBM）研究3.0T ADNI-1和ADNI-2 T1加权体积的兼容性。采用ADNI-1和ADNI-2 T1加权容积序列，使用3 T GE Signa HDx采集30例受试者的T1加权图像。使用SPM 8对图像进行预处理和分析。比较了整体灰质（GM）、白色物质（WM）和脑脊液（CSF）的体积，以及GM和WM的逐体素差异。ADNI-1和ADNI-2之间每种组织类型的相关系数和百分比差异如下：（（GM：组内相关系数（ICC）= 0.86，ADNI-1 3.09% < ADNI-2）（WM：ICC = 0.91，ADNI-1 2.92% > ADNI-2）（CSF：ICC = 0.90，ADNI-1 1.94% > ADNI-2））。对于ADNI-2，发现GM相对于ADNI-1（小脑和中央前回）广泛增加，沿中线和颞叶沿着局部减少。对于ADNI-1，发现WM相对于ADNI-2（小脑和中央前回）广泛增加，同时颞回局部减少。与ADNI-1图像相比，ADNI-2中GM的广泛增加和WM的局部减少表明使用SPM-8的图像采集方案不可直接比较。GM、WM和CSF的总体积在方案之间也以以下数量级不同：GM > WM > CSF。这对旨在分析在VBM下使用ADNI-1和ADNI-2协议获得的图像的研究具有影响。© 2014作者。International Journal of Geriatric Psychiatry，John Wiley & Sons Ltd.
The Alzheimer's Disease Neuroimaging Initiative 3.0T MRI image acquisition scheme changed between the original ADNI-1 grant and the two subsequent grants (ADNI-GO and ADNI-2). The aim of the current study was to investigate the compatibility of the 3.0T ADNI-1 and ADNI-2 T1-weighted volumes using voxel-based morphometry (VBM). T1-weighted images of 30 subjects were acquired using a 3T GE Signa HDx using the ADNI-1 and ADNI-2 T1-weighted volume sequences. Images were pre-processed and analysed using SPM8. Global grey matter (GM), white matter (WM) and cerebrospinal fluid (CSF) volumes were compared, as well as voxel-by-voxel differences in GM and WM. Correlation coefficients and percentage differences for each tissue type between ADNI-1 and ADNI-2 were as follows: ((GM: intraclass correlation coefficient (ICC) = 0.86, ADNI-1 3.09% < ADNI-2) (WM: ICC = 0.91, ADNI-1 2.92% > ADNI-2) (CSF: ICC = 0.90, ADNI-1 1.94% > ADNI-2)). For ADNI-2, widespread increases in GM were found relative to ADNI-1 (cerebellum and pre-central gyrus), with localised decreases along the midline and temporal lobes. For ADNI-1, widespread increases in WM were found relative to ADNI-2 (cerebellum and pre-central gyrus), together with localised decreases in the temporal gyrus. The widespread increase in GM and localised decrease in WM in ADNI-2 compared to ADNI-1 images suggests that the image acquisition protocols are not directly comparable using SPM-8. Total volumes of GM, WM and CSF also differed between the protocols in the following order of magnitude: GM > WM > CSF. This has implications for studies aiming to analyse images acquired using the ADNI-1 and ADNI-2 protocols under VBM. © 2014 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.
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影响因子：
2.5
作者：
Simmons, A;Arridge, SR;Williams, SCR
通讯作者：
Williams, SCR
影响因子：
5.7
作者：
Clark, KA;Woods, RP;Mazziotta, JC
通讯作者：
Mazziotta, JC
影响因子：
5.7
作者：
Ashburner, J;Friston, KJ
通讯作者：
Friston, KJ
影响因子：
7
作者：
McGraw, KO;Wong, SP
通讯作者：
Wong, SP
影响因子：
5.7
作者：
Kempton, Matthew J.;Underwood, Tracy S. A.;Brunton, Simon;Stylios, Floris;Schmechtig, Anne;Ettinger, Ulrich;Smith, Marcus S.;Lovestone, Simon;Crum, William R.;Frangou, Sophia;Williams, Steven C. R.;Simmons, Andrew
通讯作者：
Simmons, Andrew