Fermented milk of cheese-derived Lactobacillus delbrueckiisubsp.bulgaricus displays potentials in alleviating alcohol-induced hepatic injury and gut dysbiosis in mice.
Fermented milk of cheese-derived Lactobacillus delbrueckiisubsp.bulgaricus displays potentials in alleviating alcohol-induced hepatic injury and gut dysbiosis in mice.
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DOI：
10.1016/j.foodres.2022.111283
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发表时间：
2022-07-01
期刊：
影响因子：
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通讯作者：
Guo, Yuxing
中科院分区：
文献类型：
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作者：
Liu, Mingzhen;Liu, Miao;Guo, Yuxing
德氏乳杆菌（Lactobacillus delbrueckii subsp.）bulgaricus（L.保加利亚乳杆菌（Bulgaricus L7）的抗氧化能力较强。在此，我们着重评价了L。保加利亚发酵乳对急性酒精性肝病的预防使用小鼠模型，谷胱甘肽治疗的小鼠作为阳性对照。结果表明，发酵乳和谷胱甘肽均可显著减轻酒精诱导的氧化应激和炎症反应。然而，与谷胱甘肽相比，发酵奶喂养似乎更有希望恢复肠道生态失调。潜在病原体卟啉单胞菌属和肠球菌属的丰度增加，由酒精引起的，大大减弱了额外的发酵乳喂养。在本研究中，当添加谷胱甘肽时，首次观察到不同的情况，显示拟杆菌属和肠球菌属的丰度显著增加。保加利亚发酵乳在恢复酒精诱导的肠道生态失调方面的作用优于谷胱甘肽，表明其对酒精诱导的肝损伤具有潜在的保护作用。
An isolate of Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus L7) with robust antioxidant capacity was screened from traditional fermented Xinjiang cheese. Here, we focused on evaluating the effect of L. bulgaricus fermented milk on acute alcoholic liver disease prevention using a mice model, with glutathione treated mice as positive control. The results showed that both fermented milk and glutathione feeding could relieve alcohol-induced oxidative stress and inflammatory responses significantly. However, fermented milk feeding seemed to hold more promise in restoring gut dysbiosis relative to glutathione. Enhanced abundance of potential pathogens, Porphyromonas sp. and Enterococcus sp., induced by alcohol was considerably attenuated by additional feeding of fermented milk. Different scenario was firstly observed when additionally fed with glutathione in this study, showing remarkably increased abundance of Bacteroides sp. and Enterococcus sp. Our results suggested the more robust capability of L. bulgaricus fermented milk in restoring alcohol-induced gut dysbiosis relative to glutathione, indicating its potential protective effects on alcohol-induced hepatic injury.