Maternal Vitamin D Status and Risk of Gestational Diabetes: a Meta-Analysis
Maternal Vitamin D Status and Risk of Gestational Diabetes: a Meta-Analysis
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母亲维生素 D 状况和妊娠期糖尿病风险：荟萃分析
DOI：
10.1159/000486810
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发表时间：
2018-01-01
影响因子：
--
通讯作者：
Wen, Juan
中科院分区：
文献类型：
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作者：
Hu, Lingmin;Zhang, Yue;Wen, Juan
背景/目的：孕妇维生素D缺乏是否与妊娠期糖尿病相关仍有争议。本荟萃分析旨在系统地评估已发表的关于母体维生素D水平与妊娠糖尿病风险之间关系的证据。方法：我们从PubMed、Medline和Embase数据库中检索了截至2017年5月的相关文章，用于调查维生素D水平与妊娠糖尿病风险之间关系的观察性研究。使用固定效应模型和随机效应模型汇总各个研究的优势比（OR）或风险比（RR）。结果：29项观察性研究的荟萃分析包括28,982名参与者，其中4,634名被诊断为妊娠糖尿病，结果显示，母体维生素D不足与妊娠糖尿病风险显著增加39%相关（合并OR = 1.39, 95% CI = 1.20-1.60），具有中等异质性(I (2) = 50.2%；P = 0.001)。此外，妊娠糖尿病患者的25(OH) D水平显著低于对照组，合并效应为-4.79 nmol/L （95% CI = -6.43, -3.15）。异质性显著（I (2) = 65.0%, P < 0.001）。进一步的亚群分析表明，这种关联在大多数亚群中也很明显。结论：这项荟萃分析表明维生素D不足与妊娠糖尿病风险增加之间存在显著关联。进一步精心设计的大规模临床试验是验证这种关联的必要条件。(C) 2018作者：s . Karger AG，巴塞尔出版
Background/Aims: Whether maternal vitamin D deficiency is associated with gestational diabetes remains controversial. This meta-analysis aimed to systematically evaluate published evidence on the association between maternal vitamin D status and the risk of gestational diabetes. Methods: We retrieved relevant articles from the PubMed, Medline and Embase databases up to May 2017 for observational studies investigating the association between vitamin D status and the risk of gestational diabetes. Odds ratios (OR) or risk ratios (RR) from individual studies were pooled using the fixed and random effect models. Results: The meta-analysis of 29 observational studies included 28,982 participants, of which 4,634 were diagnosed with gestational diabetes, and showed that maternal vitamin D insufficiency was associated with a significantly increased risk of gestational diabetes by 39% (pooled OR = 1.39, 95% CI = 1.20-1.60) with moderate heterogeneity (I (2) = 50.2%; P = 0.001). Moreover, the 25(OH) D level was significantly lower in gestational diabetes cases than in controls with a pooled effect of -4.79 nmol/L (95% CI = -6.43, -3.15). Significant heterogeneity was also detected (I (2) = 65.0%, P < 0.001). Further subgroup analysis indicated that this association was also evident in most subpopulations. Conclusion: This meta-analysis indicated a significant association between vitamin D insufficiency and increased risk of gestational diabetes. Further well-designed large-scale clinical trials are essential to verify this association. (C) 2018 The Author(s) Published by S. Karger AG, Basel