A zinc-finger transcription factor induced by TGF-β promotes apoptotic cell death in epithelial Mv1Lu cells
A zinc-finger transcription factor induced by TGF-β promotes apoptotic cell death in epithelial Mv1Lu cells
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DOI：
10.1016/s0014-5793(99)01051-0
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发表时间：
1999-09-03
期刊：
影响因子：
3.5
通讯作者：
Ventura, F
中科院分区：
文献类型：
--
作者：
Chalaux, E;López-Rovira, T;Ventura, F
转化生长因子-β（TGF-β）超家族成员构成一组能够刺激多种细胞中的凋亡性细胞死亡的多功能因子。在这份报告中，我们表明锌指转录因子（TIEG）是上皮Mv 1 Lu细胞系中TGF-β转录诱导的立即早期基因。我们还证明，模拟TGF-β的作用，TIEG的异位过表达足以触发这些细胞中的凋亡细胞程序，这之前是Bcl-2蛋白水平的降低。最后，由TIEG过表达引起的凋亡事件可以通过Bcl-2的异位共表达有效地预防，基于这些结果，我们认为TIEG表达的诱导在TGF-β的促凋亡特性中具有作用。(C)1999年欧洲生物化学学会联合会。
Transforming growth factor-beta (TGF-beta) superfamily members constitute a group of multifunctional factors that are able to stimulate apoptotic cell death in a variety of cells. In this report, we show that a zinc-finger transcription factor (TIEG) is an immediate early gene transcriptionally induced by TGF-beta in the epithelial Mv1Lu cell line. We also demonstrate that, mimicking TGF-beta effects, ectopic overexpression of TIEG is sufficient to trigger the apoptotic cell program in these cells, which is preceded by a decrease of Bcl-2 protein levels, Finally, apoptotic events elicited by TIEG overexpression can be effectively prevented by ectopic co-expression of Bcl-2, On the basis of these results we suggest that induction of TIEG expression has a role in the pro-apoptotic properties of TGF-beta. (C) 1999 Federation of European Biochemical Societies.