The substantia innominata in alzheimer's disease: an histochemical and biochemical study of cholinergic marker enzymes
The substantia innominata in alzheimer's disease: an histochemical and biochemical study of cholinergic marker enzymes
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阿尔茨海默氏病的无名质：胆碱能标记酶的组织化学和生化研究
DOI：
10.1016/0304-3940(82)90155-0
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发表时间：
1982
影响因子：
2.5
通讯作者：
L. Iversen
中科院分区：
文献类型：
--
作者：
M. Rossor;C. Svendsen;S. Hunt;C. Mountjoy;M. Roth;L. Iversen
对 3 个正常人脑的无名质进行乙酰胆碱酯酶染色检查。在 Meynert 基底核区域内观察到大的、强烈染色的神经元，该区域被认为是动物中胆碱能投射到新皮质的起源。根据乙酰胆碱酯酶染色模式，从 19 例阿尔茨海默病 (AD) 病例和 16 例对照者死后脑组织中解剖无名质，以包括基底核。研究发现，AD 患者无名质和杏仁核的胆碱乙酰转移酶 (ChAT) 活性降低，但邻近的豆状核和下丘脑的活性并未降低。
Acetylcholinesterase staining was examined in the substantia innominata of 3 normal human brains. Large intensely stained neurones were seen within the region of the basal nucleus of Meynert which is believed to be the origin of the cholinergic projection to the neocortex in animals. On the basis of the acetylcholinesterase staining pattern, the substantia innominata was dissected from post-mortem brain tissue of 19 cases of Alzheimer's disease (AD) and 16 controls so as to include the basal nucleus. Choline acetyltransferase (ChAT) activity was found to be reduced in the substantia innominata and amygdala in AD but not in the adjacent lentiform nucleus and hypothalamus.