Increasing and supporting the participation of persons of color living with HIV/AIDS in AIDS clinical trials.
Increasing and supporting the participation of persons of color living with HIV/AIDS in AIDS clinical trials.
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DOI：
10.1007/s11904-010-0055-3
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发表时间：
2010-11
影响因子：
4.6
通讯作者：
Mildvan, Donna
中科院分区：
文献类型：
--
作者：
Gwadz, Marya Viorst;Colon, Pablo;Ritchie, Amanda S;Leonard, Noelle R;Cleland, Charles M;Riedel, Marion;Bowens, DeShannon;Banfield, Angela D;Chang, Patricia;Quiles, Robert;Mildvan, Donna
有色人种艾滋病毒/艾滋病感染者 (PLHA) 在艾滋病临床试验 (ACT) 中的代表性不足，这可能会限制研究结果的普遍性，并使许多人无法通过 ACT 获得高水平的护理和新疗法。医疗保健机构和服务提供者的招募率极低，是该群体接受 ACT 的主要障碍。此外，有色人种 PLHA 比白人同龄人更有可能拒绝参与，主要是由于恐惧和不信任（尽管意愿也很高）、关于 ACT 的负面社会规范以及难以适应不熟悉的 ACT 系统。我们描述了少量成功的行为和结构干预措施，以提高有色人种 PLHA 参与 ACT 筛查和登记的程度。 HIV 护理机构、临床试验场所和试验申办者在开发程序、支持和试验以增加 ACT 中有色人种 PLHA 的比例方面具有独特的优势。
Persons living with HIV/AIDS (PLHA) of color are under-represented in AIDS clinical trials (ACTs), which may limit the generalizability of research findings and denies many individuals access to high levels of care and new treatments available through ACTs. Disproportionately low rates of recruitment in health care settings and by providers are a major barrier to ACTs for this group. Moreover, PLHA of color are more likely than their white peers to decline to participate, mainly due to fear and mistrust (although willingness is also high), negative social norms about ACTs, and difficulty navigating the unfamiliar ACT system. We describe a small number of successful behavioral and structural interventions to increase the participation of PLHA of color in screening for and enrollment into ACTs. HIV care settings, clinical trials sites, and trial sponsors are uniquely positioned to develop procedures, supports, and trials to increase the proportion of PLHA of color in ACTs.