Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities
Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities
复制标题
DOI：
10.4049/jimmunol.174.6.3344
复制
发表时间：
2005-03-15
影响因子：
4.4
通讯作者：
Yewdell, JW
中科院分区：
文献类型：
--
作者：
Haeryfar, SMM;DiPaolo, RJ;Yewdell, JW
关于CD 4（+）CD 25（+）调节性T细胞（T-reg）在T-CD 8（+）应答中的参与知之甚少。在这项研究中，我们发现，通过抗CD 25 mAb（PC 61）处理的T-reg耗竭显著增强了T-CD 8（+）对甲型流感病毒、牛痘病毒和SV 40转化细胞的反应，这些细胞是通过直接引发或交叉引发诱导的。在CD 4缺陷小鼠中，PC61没有增强T-CD 8（+）应答，这初步证明了PC61作用于T-CD 4（+）的一个亚群，而不是表达CD 25或偶然交叉反应性Ag的其他细胞。我们进一步表明，T-reg选择性抑制反应的最免疫显性T-CD 8（+）决定因素在三个系统检查。因此，T-reg通过调节对不同决定因素的反应差异来影响T-CD 8免疫优势等级。
Little is known regarding the participation of CD4(+)CD25(+) regulatory T cells (T-reg) in T-CD8(+) responses. In this study, we show that T-reg depletion via treatment with anti-CD25 mAb (PC61) significantly enhances T-CD8(+) responses to influenza A virus, vaccinia virus, and SV40-transformed cells induced by either direct priming or cross-priming. PC61 did not enhance T-CD8(+) responses in CD4-deficient mice, providing the initial demonstration that PC61 acts on a subset of T-CD4(+), and not on other cells that express either CD25 or a fortuitously cross-reactive Ag. We further show that T-reg selectively suppress responses to the most immunodominant T-CD8(+) determinants in the three systems examined. Therefore, T-reg influence T-CD8 immunodominance hierarchies by moderating disparities in responses to different determinants.