Epigenetic information in chromatin - The code of entry for DNA repair
Epigenetic information in chromatin - The code of entry for DNA repair
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DOI：
10.4161/cc.5.7.2616
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发表时间：
2006-04-01
期刊：
影响因子：
4.3
通讯作者：
Herceg, Zdenko
中科院分区：
文献类型：
--
作者：
Loizou, Joanna I.;Murr, Rabih;Herceg, Zdenko
表观遗传学改变是人类癌症的重要病因。染色质中的表观遗传信息（称为“组蛋白密码”）是细胞用于扩展和调节遗传（DNA）密码的迷人特征。因此，提出了组蛋白密码被细胞“读取”以调节染色质DNA的可及性和功能。虽然涉及染色质修饰/重塑复合物的表观遗传密码在转录调控中的作用已经得到很好的确立，但直到最近才发现这些机制与DNA损伤检测和DNA修复有关。然而，DNA损伤传感和修复机制的组成部分如何进入致密染色质中的断裂DNA仍然是一个谜。最近的研究提供了重要的见解DNA损伤和修复特定的组蛋白修饰，并阐明了表观遗传密码如何控制DNA修复。
Epigenetic changes are important etiological factors of human cancer. Epigenetic information in chromatin (known as 'histone code') is a fascinating feature used by cells to extend and modulate the genetic (DNA) code. The histone code is thus proposed to be 'read' by cells to regulate accessibility to, and functions of, chromatin DNA. While the role of the epigenetic code involving chromatin modifying/remodeling complexes in transcriptional regulation is well established, it is only recently that these mechanisms have been implicated in DNA damage detection and DNA repair. However, how the components of the DNA damage sensing and repair machinery gain access to broken DNA in compacted chromatin remains a mystery. Recent studies provide important insights into DNA damage- and repair-specific modifications to histones and shed light on how the epigenetic code controls DNA repair.