Quantification of valve regurgitation by radionuclide angiography before and after valve replacement surgery.
Quantification of valve regurgitation by radionuclide angiography before and after valve replacement surgery.
复制标题
瓣膜置换手术前后通过放射性核素血管造影对瓣膜反流进行量化。
DOI：
10.1016/0002-9149(81)90399-4
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
R. Gorlin
中科院分区：
文献类型：
--
作者：
J. Urquhart;R. Patterson;M. Packer;S. Goldsmith;S. Horowitz;R. Litwak;R. Gorlin
放射性核素门控心脏血池成像通过计算左心室与右心室卒中计数的比值（舒张末期减去左心室和左心室感兴趣区域的收缩末期计数）来量化20例患者瓣膜返流的严重程度。主动脉瓣和二尖瓣反流患者的卒中指数比（3.91±1.45）明显高于无反流10例对照组（1.32±0.15），p < 3.001。卒中指数比率与心导管术中同时测定总卒中容量和前向卒中容量所得的反流分数密切相关（r = 0.947）。18例患者行主动脉二尖瓣置换术后，卒中指数比值从4.03±1.46降至1.38±0.23 (p < 0.001)，与无反流患者无显著差异。3例术后返流残留患者卒中指数比对照组平均值（>1.62）高出2个标准差以上，其余15例无返流迹象的患者卒中指数比在正常范围内。因此，放射性核素门控血池扫描提供了一种量化瓣膜返流和评估医学或外科干预结果的无创方法。
Radionuclide gated cardiac blood pool imaging was used to quantify the severity of valve regurgitation in 20 patients, by calculating the ratio of left ventricular to right ventricular stroke counts (end-diastolic minus end-systolic counts in right and left ventricular regions of interest). This ratio (the stroke index ratio) was substantially higher in patients with aortic and mitral regurgitation (3.91 ± 1.45) than in a control group of 10 patients without regurgitation (1.32 ± 0.15), p < 3.001. The stroke index ratio correlated closely (r = 0.947) with measurements of regurgitant fraction derived from simultaneous determinations of total and forward stroke volumes during cardiac catheterization.After aortic and mitral valve replacement in 18 patients, the stroke index ratio decreased from 4.03 ± 1.46 to 1.38 ± 0.23 (p < 0.001), a value not significantly different from that observed in patients without regurgitation. All three patients with residual postoperative regurgitation had a stroke index ratio greater than 2 standard deviations above the mean values for the control group (>1.62), whereas the remaining 15 patients, who had no evidence of regurgitation, had values within the normal range. Therefore, radionuclide gated blood pool scanning provides a noninvasive method of quantifying valve regurgitation and assessing the results of medical or surgical interventions.