Micronutrient supplements and mortality of HIV-infected adults with pulmonary TB: a controlled clinical trial.

Micronutrient supplements and mortality of HIV-infected adults with pulmonary TB: a controlled clinical trial.
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发表时间：
2007-08
期刊：
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
影响因子：
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通讯作者：
R. Semba;J. Kumwenda;Eduard E. Zijlstra;M. Ricks;M. Lettow;Christopher C. Whalen;Tamara D. Clark;L. Jørgensen;J. Kohler;N. Kumwenda;T. Taha;A. Harries
R. Semba;J. Kumwenda;Eduard E. Zijlstra;M. Ricks;M. Lettow;Christopher C. Whalen;Tamara D. Clark;L. Jørgensen;J. Kohler;N. Kumwenda;T. Taha;A. Harries
中科院分区：
其他
文献类型：
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作者：
R. Semba;J. Kumwenda;Eduard E. Zijlstra;M. Ricks;M. Lettow;Christopher C. Whalen;Tamara D. Clark;L. Jørgensen;J. Kohler;N. Kumwenda;T. Taha;A. Harries

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SETTING Zomba and Blantyre, Malawi, Africa. OBJECTIVES To determine whether daily micronutrient supplementation reduces the mortality of human immunodeficiency virus (HIV) infected adults with pulmonary tuberculosis (TB). DESIGN A randomised, controlled clinical trial of micronutrient supplementation for HIV-positive and HIV-negative adults with pulmonary TB. Participants were enrolled at the commencement of chemotherapy for sputum smear-positive pulmonary TB and followed up for 24 months. RESULTS A total of 829 HIV-positive and 573 HIV-negative adults were enrolled. During follow-up, 328 HIV-positive and 17 HIV-negative participants died. The proportion of HIV-positive participants who died in the micronutrient and placebo groups was 38.7% and 40.4%, respectively (P = 0.49). Micronutrient supplementation did not reduce mortality (hazard ratio [HR] 0.93, 95%CI 0.75-1.15) among HIV-positive adults. CONCLUSIONS Micronutrient supplementation at the doses used in this study does not reduce mortality in HIV-positive adults with pulmonary TB in Malawi.