Induction of vitellogenin synthesis by nonylphenol and 17β-estradiol and effects on the testicular structure in the eelpout Zoarces viviparus
Induction of vitellogenin synthesis by nonylphenol and 17β-estradiol and effects on the testicular structure in the eelpout Zoarces viviparus
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DOI：
10.1016/s0141-1136(97)00046-9
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发表时间：
1998-07-01
影响因子：
3.3
通讯作者：
Jespersen, A
中科院分区：
文献类型：
--
作者：
Christiansen, T;Korsgaard, B;Jespersen, A
在本研究中，壬基酚或17 β-雌二醇对卵黄蛋白原的合成和睾丸结构的影响进行了研究，在男性Eelpouts Zoarces viviparus在活跃的精子发生（5月）和后期精子发生（6月）。壬基酚或雌二醇处理导致血浆卵黄蛋白原浓度显著增加，同时性腺指数显著降低。组织学检查显示对睾丸有严重影响。对照组的生精小叶含有精囊（5月）或立方支持细胞（6月）。在处理的鱼，小叶退化（5月）或充满精子，并有鳞状支持细胞含有吞噬精子细胞（6月）。结果表明，壬基酚具有雌激素样作用，对胎生带状疱疹的睾丸有明显的影响。(C)1998爱思唯尔科技有限公司版权所有。
In the present study the effect of nonylphenol or 17 beta-estradiol on vitellogenin synthesis and testicular structure was investigated in male eelpouts Zoarces viviparus during active spermatogenesis (May) and at late spermatogenesis (June). Nonylphenol or estradiol treatment resulted in a significant increase ill the plasma vitellogenin concentration concomitant with a significant reduction in the gonadosomatic index. Histological examination revealed severe effects on the testis. Controls had seminiferous lobules containing spermatocysts (May) or cuboidal Sertoli cells (June). In treated fish, lobules were degenerated (May) or were filled with spermatozoa and had squamous Sertoli cells containing phagocytized sperm cells (June). The results indicate that nonylphenol is estrogenic and has marked effects on the testis of Zoarces viviparus. (C) 1998 Elsevier Science Ltd. All rights reserved.