Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature
Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature
复制标题
DOI：
10.1126/science.1164594
复制
发表时间：
2008-11-21
期刊：
影响因子：
56.9
通讯作者：
McMahon, Andrew P.
中科院分区：
文献类型：
--
作者：
Stenman, Jan M.;Rajagopal, Jay;McMahon, Andrew P.
每个器官都依赖于血管提供氧气和营养，但是与单个器官相关的血管系统在结构和分子上是多样的。中枢神经系统（CNS）的血管系统由紧密密封的内皮构成血脑屏障，而其他器官的血管则多孔得多。Wnt7a和Wnt7b编码两个Wnt配体，这些配体是由发育中的中枢神经系统的神经上皮在血管侵袭时产生的。通过小鼠遗传模型，我们发现这些配体直接靶向血管内皮，中枢神经系统使用典型的Wnt信号通路来促进器官血管的形成和中枢神经系统特异性分化。
Every organ depends on blood vessels for oxygen and nutrients, but the vasculature associated with individual organs can be structurally and molecularly diverse. The central nervous system (CNS) vasculature consists of a tightly sealed endothelium that forms the blood- brain barrier, whereas blood vessels of other organs are more porous. Wnt7a and Wnt7b encode two Wnt ligands produced by the neuroepithelium of the developing CNS coincident with vascular invasion. Using genetic mouse models, we found that these ligands directly target the vascular endothelium and that the CNS uses the canonical Wnt signaling pathway to promote formation and CNS- specific differentiation of the organ's vasculature.